ABL2
Nowadays, ABL2 is a theme that has captured the attention of people all over the world. Whether because of its relevance in today's society, its impact on people's lives, or its role in history, ABL2 has generated constant debate and sparked the interest of researchers, experts, and ordinary people alike. In this article, we will explore the topic of ABL2 in depth, analyzing its different facets, its implications in society and its relevance in today's world. Through an enriching and detailed approach, we will seek to better understand what ABL2 is, why it is important and how it influences our daily lives.
Tyrosine-protein kinase ABL2 also known as Abelson-related gene (Arg) is an enzyme that in humans is encoded by the ABL2 gene.[5][6]
Function
ABL2 is a cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal and tumor cells. The expression of ABL2 gene is higher in KRAS mutant non-small cell lung cancer.[7] The ABL2 gene product is expressed as two variants bearing different amino termini, both approximately 12-kb in length.[6]
Interactions
ABL2 has been shown to interact with three proteins: Abl gene,[8] catalase,[9] and SORBS2.[10] The protein Abl gene is also known as abelson murine leukemia viral oncogene homolog 1 and is a protein that is encoded by the human ABL1 gene.[11] Catalase is a common enzyme that catalyzes the decomposition of hydrogen peroxide to water and oxygen.[12] SORBS2 is also known as Sorbin and SH3 domain-containing protein 2 and is a protein encoded by the SORBS2 gene in humans.[6][10][13]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000143322 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026596 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Kruh GD, King CR, Kraus MH, Popescu NC, Amsbaugh SC, McBride WO, et al. (December 1986). "A novel human gene closely related to the abl proto-oncogene". Science. 234 (4783): 1545–1548. Bibcode:1986Sci...234.1545K. doi:10.1126/science.3787260. PMID 3787260.
- ^ a b c "Entrez Gene: ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)".
- ^ Nagy Á, Pongor LS, Szabó A, Santarpia M, Győrffy B (February 2017). "KRAS driven expression signature has prognostic power superior to mutation status in non-small cell lung cancer". International Journal of Cancer. 140 (4): 930–937. doi:10.1002/ijc.30509. PMC 5299512. PMID 27859136.
- ^ Cao C, Leng Y, Li C, Kufe D (April 2003). "Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response". The Journal of Biological Chemistry. 278 (15): 12961–12967. doi:10.1074/jbc.M300058200. PMID 12569093.
- ^ Cao C, Leng Y, Kufe D (August 2003). "Catalase activity is regulated by c-Abl and Arg in the oxidative stress response". The Journal of Biological Chemistry. 278 (32): 29667–29675. doi:10.1074/jbc.M301292200. PMID 12777400.
- ^ a b Wang B, Golemis EA, Kruh GD (July 1997). "ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks". The Journal of Biological Chemistry. 272 (28): 17542–17550. doi:10.1074/jbc.272.28.17542. hdl:20.500.12613/9174. PMID 9211900.
- ^ Szczylik C, Skorski T, Nicolaides NC, Manzella L, Malaguarnera L, Venturelli D, et al. (August 1991). "Selective inhibition of leukemia cell proliferation by BCR-ABL antisense oligodeoxynucleotides". Science. 253 (5019): 562–565. Bibcode:1991Sci...253..562S. doi:10.1126/science.1857987. PMID 1857987.
- ^ Chelikani P, Fita I, Loewen PC (January 2004). "Diversity of structures and properties among catalases". Cellular and Molecular Life Sciences. 61 (2): 192–208. doi:10.1007/s00018-003-3206-5. hdl:10261/111097. PMC 11138816. PMID 14745498. S2CID 4411482.
- ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, et al. (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–286. doi:10.1093/dnares/5.5.277. PMID 9872452.
Further reading
- Bradley WD, Koleske AJ (October 2009). "Regulation of cell migration and morphogenesis by Abl-family kinases: emerging mechanisms and physiological contexts". Journal of Cell Science. 122 (Pt 19): 3441–3454. doi:10.1242/jcs.039859. PMC 2746129. PMID 19759284.
- Pendergast AM (2003). "The Abl family kinases: mechanisms of regulation and signaling". Advances in Cancer Research. 85: 51–100. doi:10.1016/S0065-230X(02)85003-5. ISBN 978-0-12-006685-8. PMID 12374288.
- Muller AJ, Pendergast AM, Havlik MH, Puil L, Pawson T, Witte ON (November 1992). "A limited set of SH2 domains binds BCR through a high-affinity phosphotyrosine-independent interaction". Molecular and Cellular Biology. 12 (11): 5087–5093. doi:10.1128/mcb.12.11.5087. PMC 360442. PMID 1383690.
- Kruh GD, Perego R, Miki T, Aaronson SA (August 1990). "The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases". Proceedings of the National Academy of Sciences of the United States of America. 87 (15): 5802–5806. Bibcode:1990PNAS...87.5802K. doi:10.1073/pnas.87.15.5802. PMC 54416. PMID 2198571.
- Kruh GD, King CR, Kraus MH, Popescu NC, Amsbaugh SC, McBride WO, et al. (December 1986). "A novel human gene closely related to the abl proto-oncogene". Science. 234 (4783): 1545–1548. Bibcode:1986Sci...234.1545K. doi:10.1126/science.3787260. PMID 3787260.
- Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Wang B, Kruh GD (July 1996). "Subcellular localization of the Arg protein tyrosine kinase". Oncogene. 13 (1): 193–197. PMID 8700546.
- Wang B, Mysliwiec T, Feller SM, Knudsen B, Hanafusa H, Kruh GD (October 1996). "Proline-rich sequences mediate the interaction of the Arg protein tyrosine kinase with Crk". Oncogene. 13 (7): 1379–1385. PMID 8875975.
- Wang B, Golemis EA, Kruh GD (July 1997). "ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks". The Journal of Biological Chemistry. 272 (28): 17542–17550. doi:10.1074/jbc.272.28.17542. hdl:20.500.12613/9174. PMID 9211900.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Koval AP, Blakesley VA, Roberts CT, Zick Y, Leroith D (March 1998). "Interaction in vitro of the product of the c-Crk-II proto-oncogene with the insulin-like growth factor I receptor". The Biochemical Journal. 330 ( Pt 2) (Pt 2): 923–932. doi:10.1042/bj3300923. PMC 1219226. PMID 9480911.
- Hashimoto Y, Katayama H, Kiyokawa E, Ota S, Kurata T, Gotoh N, et al. (July 1998). "Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptor". The Journal of Biological Chemistry. 273 (27): 17186–17191. doi:10.1074/jbc.273.27.17186. PMID 9642287.
- Danial NN, Losman JA, Lu T, Yip N, Krishnan K, Krolewski J, et al. (November 1998). "Direct interaction of Jak1 and v-Abl is required for v-Abl-induced activation of STATs and proliferation". Molecular and Cellular Biology. 18 (11): 6795–6804. doi:10.1128/mcb.18.11.6795. PMC 109263. PMID 9774693.
- Cao C, Ren X, Kharbanda S, Koleske AJ, Prasad KV, Kufe D (April 2001). "The ARG tyrosine kinase interacts with Siva-1 in the apoptotic response to oxidative stress". The Journal of Biological Chemistry. 276 (15): 11465–11468. doi:10.1074/jbc.C100050200. PMC 3476318. PMID 11278261.
- Yu HH, Zisch AH, Dodelet VC, Pasquale EB (July 2001). "Multiple signaling interactions of Abl and Arg kinases with the EphB2 receptor". Oncogene. 20 (30): 3995–4006. doi:10.1038/sj.onc.1204524. PMID 11494128.
- Endo A, Nagashima K, Kurose H, Mochizuki S, Matsuda M, Mochizuki N (June 2002). "Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and CrkII". The Journal of Biological Chemistry. 277 (26): 23747–23754. doi:10.1074/jbc.M111794200. PMID 11956190.
- Abassi YA, Vuori K (September 2002). "Tyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling". The EMBO Journal. 21 (17): 4571–4582. doi:10.1093/emboj/cdf446. PMC 126186. PMID 12198159.
- Bianchi C, Muradore I, Corizzato M, Cornacchini G, Beretta L, Erba E, et al. (September 2002). "The expression of the non-receptor tyrosine kinases Arg and c-abl is differently modulated in B lymphoid cells at different stages of differentiation". FEBS Letters. 527 (1–3): 216–222. Bibcode:2002FEBSL.527..216B. doi:10.1016/S0014-5793(02)03233-7. PMID 12220663.
- Salomon AR, Ficarro SB, Brill LM, Brinker A, Phung QT, Ericson C, et al. (January 2003). "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry". Proceedings of the National Academy of Sciences of the United States of America. 100 (2): 443–448. Bibcode:2003PNAS..100..443S. doi:10.1073/pnas.2436191100. PMC 141014. PMID 12522270.
External links
- Genes,+abl at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Abelson+Leukemia+Virus at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- ABL2 Info with links in the Cell Migration Gateway
- Human ABL2 genome location and ABL2 gene details page in the UCSC Genome Browser.
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