AM-2232

This article will address the topic of AM-2232, which has become very relevant today. AM-2232 is a topic of great importance that has aroused great interest in various areas, from academics to the general public. Over the years, AM-2232 has generated debates, controversies and significant advances, which demonstrates its importance and significance in today's society. Through a detailed analysis, different aspects related to AM-2232 will be explored, with the aim of providing a comprehensive and enriching vision on this topic.

Cannabinoid receptor agonist

Pharmaceutical compound

AM-2232

Legal status
Legal status	CA: Schedule II DE: Anlage II (Authorized trade only, not prescriptible) NZ: Temporary Class UK: Class B US: Schedule I
Identifiers
IUPAC name 5-(3-(1-Naphthoyl)-1H-indol-1-yl)pentanenitrile
CAS Number	335161-19-8 N
ChemSpider	26633898 N
UNII	40KCH8YIKP
CompTox Dashboard (EPA)	DTXSID90187157
Chemical and physical data
Formula	C24H20N2O
Molar mass	352.437 g·mol−1
3D model (JSmol)	Interactive image
SMILES c1ccc2c(c1)cccc2C(=O)c3cn(c4c3cccc4)CCCCC#N
InChI InChI=1S/C24H20N2O/c25-15-6-1-7-16-26-17-22(20-12-4-5-14-23(20)26)24(27)21-13-8-10-18-9-2-3-11-19(18)21/h2-5,8-14,17H,1,6-7,16H2 N Key:VWVAIBKHFCUSMD-UHFFFAOYSA-N N
NY (what is this?)  (verify)

AM-2232 (1-(4-cyanobutyl)-3-(naphthalen-1-oyl)indole) is a drug that acts as a potent but unselective agonist for the cannabinoid receptors, with a K_i of 0.28 nM at CB₁ and 1.48 nM at CB₂.^[1][2]

In the United States, all CB₁ receptor agonists of the 3-(1-naphthoyl)indole class such as AM-2232 are Schedule I Controlled Substances.^[3]

See also

• AM-694
• AM-1235
• AM-2233
• FUBIMINA
• JWH-018
• List of AM cannabinoids
• List of JWH cannabinoids
• O-774
• O-1057
• O-1812
• THJ-2201

References

1. ^ US patent 7241799, Makriyannis A, Deng H, "Cannabimimetic indole derivatives", granted 2007-07-10 
2. ^ Zagzoog A, Brandt AL, Black T, Kim ED, Burkart R, Patel M, Jin Z, Nikolaeva M, Laprairie RB (May 2021). "Assessment of select synthetic cannabinoid receptor agonist bias and selectivity between the type 1 and type 2 cannabinoid receptor". Scientific Reports. 11 (1) 10611. Bibcode:2021NatSR..1110611Z. doi:10.1038/s41598-021-90167-w. PMC 8134483. PMID 34012003.
3. ^ 21 U.S.C. § 812: Schedules of controlled substances

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