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Befetupitant

In today's article we are going to talk about Befetupitant, a topic that has caught the attention of many people in recent times. Befetupitant has become a topic of interest for society due to its relevance and impact in different areas of daily life. Throughout the article, we will analyze different aspects related to Befetupitant, from its origin to its evolution over time, including its implications in today's society. In addition, we will explore different perspectives and opinions on Befetupitant, with the aim of providing a broad and complete overview of this very relevant topic. Don't miss this interesting article about Befetupitant!

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Befetupitant
Clinical data
ATC code
  • none
Identifiers
  • 2--N,2-dimethyl-N-propanamide
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC29H29F6N3O2
Molar mass565.560 g·mol−1
3D model (JSmol)
  • CC1=CC=CC=C1C2=CC(=NC=C2N(C)C(=O)C(C)(C)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)N4CCOCC4
  • InChI=1S/C29H29F6N3O2/c1-18-7-5-6-8-22(18)23-16-25(38-9-11-40-12-10-38)36-17-24(23)37(4)26(39)27(2,3)19-13-20(28(30,31)32)15-21(14-19)29(33,34)35/h5-8,13-17H,9-12H2,1-4H3
  • Key:ZGNPLCMMVKCTHM-UHFFFAOYSA-N

Befetupitant (Ro67-5930) is a drug developed by Hoffmann-La Roche which acts as a potent and selective antagonist for the NK1 receptor.[1] It was originally developed as a potential antiemetic drug, though development was ultimately discontinued after a related drug netupitant was deemed to be more suitable for clinical development. Befetupitant has however continued to be researched for other possible applications such as treatment of corneal neovascularization.[2]

References

  1. ^ Hoffmann T, Bös M, Stadler H, Schnider P, Hunkeler W, Godel T, et al. (March 2006). "Design and synthesis of a novel, achiral class of highly potent and selective, orally active neurokinin-1 receptor antagonists". Bioorganic & Medicinal Chemistry Letters. 16 (5): 1362–5. doi:10.1016/j.bmcl.2005.11.047. PMID 16332435.
  2. ^ Bignami F, Giacomini C, Lorusso A, Aramini A, Rama P, Ferrari G (September 2014). "NK1 receptor antagonists as a new treatment for corneal neovascularization". Investigative Ophthalmology & Visual Science. 55 (10): 6783–94. doi:10.1167/iovs.14-14553. PMID 25228541.
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