Today, we enter the fascinating world of Botzinger complex. Throughout history, Botzinger complex has aroused the interest and curiosity of countless people, whether due to its impact on society, its significance in the cultural sphere or its relevance in different aspects of daily life. Through this article, we aim to explore and analyze in depth all aspects related to Botzinger complex, from its origins to its possible implications in the future. We will delve into its many facets, unraveling its importance and value in the current context, with the aim of providing our readers with a complete and enriching vision of this exciting topic.
In mammals, the Bötzinger complex (BötC) is a group of neurons located in the rostral ventrolateral medulla, and ventral respiratory column. In the medulla, this group is located caudally to the facial nucleus and ventral to nucleus ambiguus.
Function
The Bötzinger complex plays an important role in controlling breathing and responding to hypoxia. The Bötzinger complex consists primarily of glycinergic neurons which inhibit respiratory activity. Of the respiratory cycle phases BötC generates post-inspiratory (Post-I) activity and augmenting expiratory (aug-e) activity.
Name
The Bötzinger complex was named by UCLA Professor Jack Feldman in 1978, after a bottle of white wine named Botzinger present at his table during a scientific meeting in Hirschhorn, Germany, that year.[citation needed]
Only augmenting expiratory neurons of BötC, which are exclusively glycinergic, project to the phrenic nucleus.
Projections to the Bötzinger complex include the nucleus tractus solitarii (NTS) the DRG and the VRG.
Physiology
These neurons are intrinsic pacemakers. Post-I neurons display an initial burst of activity followed by decrease in activity at the end of inspiration. Aug-E neurons begin firing during the E2 phase and end before the phrenic nerve burst.
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