CLCA4

In this article we will explore in depth the topic of CLCA4, which has generated great interest and debate in different areas. From its origins to its relevance today, we will examine how CLCA4 has impacted our lives and society at large. With a multidisciplinary approach, we will analyze various aspects related to CLCA4, from its influence in popular culture to its importance in the scientific field. Through this article, we seek to provide a comprehensive and enriching vision of CLCA4, with the aim of expanding knowledge and generating deep reflections on this intriguing topic.

Protein-coding gene in humans

CLCA4
Identifiers
Aliases	CLCA4, CaCC, CaCC2, chloride channel accessory 4
External IDs	OMIM: 616857; MGI: 2139744; HomoloGene: 40808; GeneCards: CLCA4; OMA:CLCA4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p22.3 Start 86,547,078 bp[1] End 86,580,754 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 H2 Start 144,658,241 bp[2] End 144,680,806 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of colon mucosa of sigmoid colon oral cavity mucosa of pharynx rectum mucosa of transverse colon cervix epithelium mucosa of urinary bladder mucosa of ileum nasal epithelium Top expressed in jejunum Paneth cell left colon ileum duodenum conjunctival fornix lumbar subsegment of spinal cord cornea ciliary body embryo More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase activity hydrolase activity metallopeptidase activity metal ion binding chloride channel activity metalloendopeptidase activity intracellular calcium activated chloride channel activity Cellular component integral component of membrane extracellular region plasma membrane integral component of plasma membrane apical plasma membrane membrane Biological process ion transmembrane transport chloride transport proteolysis chloride transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22802 99663 Ensembl ENSG00000016602 ENSMUSG00000068547 UniProt Q14CN2 Q6Q473 RefSeq (mRNA) NM_012128 NM_207208 RefSeq (protein) NP_036260 NP_997091 Location (UCSC) Chr 1: 86.55 – 86.58 Mb Chr 3: 144.66 – 144.68 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Chloride channel accessory 4, also known as CLCA4, is a protein which in humans CLCA4 gene. The protein encoded by this gene is a chloride channel.^[5] Protein structure prediction methods suggest the N-terminal region of CLCA4 protein is a zinc metalloprotease, and the protein is not an ion channel per se.^[6]

See also

• Chloride channel

References

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000016602 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000068547 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Agnel M, Vermat T, Culouscou JM (July 1999). "Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea". FEBS Lett. 455 (3): 295–301. doi:10.1016/S0014-5793(99)00891-1. PMID 10437792. S2CID 82094058.
6. ^ Pawłowski K, Lepistö M, Meinander N, et al. (2006). "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels". Proteins. 63 (3): 424–39. doi:10.1002/prot.20887. PMID 16470849. S2CID 40041491.

Further reading

• Liu QH, Williams DA, McManus C, et al. (2000). "HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4832–7. Bibcode:2000PNAS...97.4832L. doi:10.1073/pnas.090521697. PMC 18318. PMID 10758170.
• Ritzka M, Stanke F, Jansen S, et al. (2004). "The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis". Hum. Genet. 115 (6): 483–91. doi:10.1007/s00439-004-1190-y. PMID 15490240. S2CID 12935280.
• Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Pauli BU, Abdel-Ghany M, Cheng HC, et al. (2000). "Molecular characteristics and functional diversity of CLCA family members". Clin. Exp. Pharmacol. Physiol. 27 (11): 901–5. doi:10.1046/j.1440-1681.2000.03358.x. PMID 11071307. S2CID 28762005.

External links

• CLCA3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human CLCA4 genome location and CLCA4 gene details page in the UCSC Genome Browser.

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