COPZ1

The topic of COPZ1 is one that has been widely discussed over the years. With divergent opinions and varied points of view, COPZ1 has captured the interest of experts and enthusiasts alike. In this article, we will explore the different facets of COPZ1, offering a comprehensive analysis covering its history, impact, and possible implications for the future. From its origin to its current evolution, COPZ1 has left a significant mark on the world that deserves meticulous and detailed attention.

Protein-coding gene in humans

COPZ1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2HF6, 5A1U, 5A1V, 5A1W, 5A1X, 5A1Y
Identifiers
Aliases	COPZ1, COPZ, HSPC181, zeta-COP, zeta1-COP, CGI-120, coatomer protein complex subunit zeta 1, COPI coat complex subunit zeta 1
External IDs	OMIM: 615472; MGI: 1929063; HomoloGene: 9366; GeneCards: COPZ1; OMA:COPZ1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.13 Start 54,301,202 bp[1] End 54,351,846 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F3|15 58.74 cM Start 103,181,141 bp[2] End 103,208,295 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans body of pancreas ventricular zone stromal cell of endometrium ganglionic eminence rectum monocyte right adrenal gland gallbladder smooth muscle tissue Top expressed in yolk sac dermis duodenum right kidney epithelium of stomach human fetus jejunum islet of Langerhans neural tube choroid plexus of fourth ventricle More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 22818 56447 Ensembl ENSG00000111481 ENSMUSG00000060992 UniProt P61923 P61924 RefSeq (mRNA) NM_001271734 NM_001271735 NM_001271736 NM_016057 NM_019817 NM_001357748 RefSeq (protein) NP_001258663 NP_001258664 NP_001258665 NP_057141 NP_062791 NP_001344677 Location (UCSC) Chr 12: 54.3 – 54.35 Mb Chr 15: 103.18 – 103.21 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Coatomer subunit zeta-1 is a protein that in humans is encoded by the COPZ1 gene.^[5]

Interactions

COPZ1 has been shown to interact with COPG.^[6][7]

References

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000111481 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000060992 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "Entrez Gene: COPZ1 coatomer protein complex, subunit zeta 1".
6. ^ Futatsumori M, Kasai K, Takatsu H, Shin HW, Nakayama K (November 2000). "Identification and characterization of novel isoforms of COP I subunits". J. Biochem. 128 (5): 793–801. doi:10.1093/oxfordjournals.jbchem.a022817. PMID 11056392.
7. ^ Faulstich D, Auerbach S, Orci L, Ravazzola M, Wegchingel S, Lottspeich F, Stenbeck G, Harter C, Wieland FT, Tschochner H (Oct 1996). "Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex" (PDF). J. Cell Biol. 135 (1): 53–61. doi:10.1083/jcb.135.1.53. PMC 2121028. PMID 8858162.

External links

• Human COPZ1 genome location and COPZ1 gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: P61923 (Human Coatomer subunit zeta-1) at the PDBe-KB.

Further reading

• Pelham HR, Rothman JE (2000). "The debate about transport in the Golgi--two sides of the same coin?". Cell. 102 (6): 713–9. doi:10.1016/S0092-8674(00)00060-X. PMID 11030615. S2CID 18044044.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Pavel J, Harter C, Wieland FT (1998). "Reversible dissociation of coatomer: functional characterization of a beta/delta-coat protein subcomplex". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2140–5. Bibcode:1998PNAS...95.2140P. doi:10.1073/pnas.95.5.2140. PMC 19276. PMID 9482852.
• Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
• Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Futatsumori M, Kasai K, Takatsu H, Shin HW, Nakayama K (2001). "Identification and characterization of novel isoforms of COP I subunits". J. Biochem. 128 (5): 793–801. doi:10.1093/oxfordjournals.jbchem.a022817. PMID 11056392.

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