DNAJC7

In today's world, DNAJC7 is a topic that has captured the attention of millions of people around the world. With his impact on society, culture and the economy, DNAJC7 has become a prominent figure in modern life. From his influence on social media to his role in politics, DNAJC7 has proven to be a fascinating and relevant topic in the contemporary world. In this article, we will explore the various facets of DNAJC7 and analyze its impact on different aspects of everyday life.

Protein-coding gene in the species Homo sapiens

DNAJC7
Identifiers
Aliases	DNAJC7, DJ11, DJC7, TPR2, TTC2, DnaJ heat shock protein family (Hsp40) member C7
External IDs	OMIM: 601964; MGI: 1928373; HomoloGene: 68306; GeneCards: DNAJC7; OMA:DNAJC7 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.2 Start 41,976,421 bp[1] End 42,021,376 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 D|11 63.47 cM Start 100,473,644 bp[2] End 100,511,014 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nucleus accumbens caudate nucleus right frontal lobe anterior pituitary monocyte mucosa of transverse colon apex of heart cingulate gyrus Brodmann area 9 anterior cingulate cortex Top expressed in tail of embryo neural layer of retina ventricular zone genital tubercle superior frontal gyrus thymus ganglionic eminence cerebellar cortex primary visual cortex trigeminal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding heat shock protein binding ATPase activator activity Cellular component cytoplasm extracellular exosome cytoskeleton membrane nucleus nucleoplasm cytosol Biological process regulation of cellular response to heat protein folding positive regulation of ATP-dependent activity chaperone cofactor-dependent protein refolding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7266 56354 Ensembl ENSG00000168259 ENSMUSG00000014195 UniProt Q99615 Q9QYI3 RefSeq (mRNA) NM_001144766 NM_003315 NM_019795 NM_001378962 NM_001378963 RefSeq (protein) NP_001138238 NP_003306 NP_062769 NP_001365891 NP_001365892 Location (UCSC) Chr 17: 41.98 – 42.02 Mb Chr 11: 100.47 – 100.51 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

DnaJ homolog subfamily C member 7 is a protein that in humans is encoded by the DNAJC7 gene.^[5][6][7]

Interactions

DNAJC7 has been shown to interact with RAD9A.^[8]

References

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000168259 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000014195 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Murthy AE, Bernards A, Church D, Wasmuth J, Gusella JF (Nov 1996). "Identification and characterization of two novel tetratricopeptide repeat-containing genes". DNA Cell Biol. 15 (9): 727–35. doi:10.1089/dna.1996.15.727. PMID 8836031.
6. ^ Ohtsuka K, Hata M (Jan 2001). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature". Cell Stress Chaperones. 5 (2): 98–112. doi:10.1379/1466-1268(2000)005<0098:mhdhco>2.0.co;2 (inactive 12 July 2025). PMC 312896. PMID 11147971.{{cite journal}}: CS1 maint: DOI inactive as of July 2025 (link)
7. ^ "Entrez Gene: DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7".
8. ^ Xiang SL, Kumano T, Iwasaki SI, Sun X, Yoshioka K, Yamamoto KC (2001). "The J domain of Tpr2 regulates its interaction with the proapoptotic and cell-cycle checkpoint protein, Rad9". Biochem. Biophys. Res. Commun. 287 (4): 932–40. doi:10.1006/bbrc.2001.5685. hdl:2297/1794. PMID 11573955. S2CID 20694221.

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Xiang SL, Kumano T, Iwasaki SI, et al. (2001). "The J domain of Tpr2 regulates its interaction with the proapoptotic and cell-cycle checkpoint protein, Rad9". Biochem. Biophys. Res. Commun. 287 (4): 932–40. doi:10.1006/bbrc.2001.5685. hdl:2297/1794. PMID 11573955. S2CID 20694221.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Brychzy A, Rein T, Winklhofer KF, et al. (2003). "Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system". EMBO J. 22 (14): 3613–23. doi:10.1093/emboj/cdg362. PMC 165632. PMID 12853476.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

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