This article will address the topic of Dystrophic calcification, which has aroused growing interest in recent times. From different perspectives and approaches, this topic has generated debates and reflections in various areas, such as society, culture, politics, economics and science. Its implications, its evolution over time and its relevance today will be explored, with the aim of offering a comprehensive and detailed vision of Dystrophic calcification. Its different dimensions will be examined, analyzing its consequences, its influence on the global level and its future projection. Through a deep and exhaustive analysis, the aim is to contribute to the understanding and knowledge of Dystrophic calcification, thus enriching the debate and reflection around this topic of undoubted importance.
Calcification occurring in degenerated or necrotic tissue
Dystrophic calcification (DC) is the calcification occurring in degenerated or necrotic tissue, as in hyalinized scars, degenerated foci in leiomyomas, and caseous nodules. This occurs as a reaction to tissue damage, including as a consequence of medical device implantation. Dystrophic calcification can occur even if the amount of calcium in the blood is not elevated, in contrast to metastatic calcification, which is a consequence of a systemic mineral imbalance, including hypercalcemia and/or hyperphosphatemia, that leads to calcium deposition in healthy tissues. In dystrophic calcification, basophilic calcium salt deposits aggregate, first in the mitochondria, then progressively throughout the cell.[citation needed] These calcifications are an indication of previous microscopic cell injury, occurring in areas of cell necrosis when activated phosphatases bind calcium ions to phospholipids in the membrane.
Calcification in dead tissue
Caseous necrosis in T.B. is most common site of dystrophic calcification.