EIF2B
Today, EIF2B is a topic that has gained indisputable relevance in modern society. From EIF2B people have debated its impact on our lives, its influence on different aspects of culture and its role in the evolution of technology. This phenomenon has sparked increasing interest in various fields, from politics and economics to psychology and medicine. In this article, we will explore the various facets of EIF2B and its importance in today's world, examining its impact on society and its potential to transform the way we think and act.
eIF2B is a protein complex found in eukaryotes. It is the guanine nucleotide exchange factor for the eukaryotic initiation factor 2 and therefore converts the inactive eIF2-GDP to the active eIF2-GTP. This activation is hindered by phosphorylation of the alpha subunit of eIF2, which leads to a stable eIF2α-P-GDP-eIF2B complex and therefore inhibits translation initiation.[1]
Human genes which encode eIF-2B proteins include:
- EIF2B1 – alpha subunit (26kDa)
- EIF2B2 – beta subunit (39kDa)
- EIF2B3 – gamma subunit (58kDa)
- EIF2B4 – delta subunit (67kDa)
- EIF2B5 – epsilon subunit (82kDa)
References
- ^ Pavitt, G.D. (Dec 2005). "eIF2B, a mediator of general and gene-specific translational control". Biochem Soc Trans. 33 (Pt 6): 1487–92. doi:10.1042/BST20051487. PMID 16246152.
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