ICP8
In today's article we are going to delve into the fascinating world of ICP8. We will examine its origins, its relevance today and its impact on different aspects of our society. ICP8 has been the subject of study and debate for years, and in this article we will try to shed new light on this exciting topic. From its beginnings to its evolution today, we will explore all facets of ICP8 and how it has influenced the way we think, live and relate to the world around us. Get ready to embark on this exciting adventure of discovery and knowledge!
ICP8, the herpes simplex virus type-1 single-strand DNA-binding protein, is one of seven proteins encoded in the viral genome of HSV-1 that is required for HSV-1 DNA replication.[1] It is able to anneal to single-stranded DNA (ssDNA) as well as melt small fragments of double-stranded DNA (dsDNA);[1] its role is to destabilize duplex DNA during initiation of replication. It differs from helicases because it is ATP- and Mg2+-independent.[1] In cells infected with HSV-1, the DNA in those cells become colocalized with ICP8.
ICP8 is required in late gene transcription, and has found to be associated with cellular RNA polymerase II holoenzyme.[2]
See also
References
- ^ a b c Boehmer, PE; Lehman, IR (1993). "Herpes simplex virus type 1 ICP8: Helix-destabilizing properties". Journal of Virology. 67 (2): 711–5. PMC 237422. PMID 8380461.
- ^ Zhou, C; Knipe, DM (2002). "Association of herpes simplex virus type 1 ICP8 and ICP27 proteins with cellular RNA polymerase II holoenzyme". Journal of Virology. 76 (12): 5893–904. doi:10.1128/JVI.76.12.5893-5904.2002. PMC 136207. PMID 12021322.