In this article, we will explore the fascinating world of IL22RA1 and everything that this concept entails. From its origins to its evolution today, IL22RA1 has played a crucial role in different areas of society. Through detailed analysis, we will examine the influence of IL22RA1 on culture, science, politics, and many other aspects of everyday life. In addition, we will learn about the different perspectives and opinions that exist about IL22RA1, as well as the controversies it has raised over time. In short, this article aims to offer a comprehensive and enriching vision of IL22RA1, with the aim of deepening its understanding and its impact on today's world.
Interleukin 22 receptor, alpha 1 is a protein that in humans is encoded by the IL22RA1 gene.[5]
Function
The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22). IL22 receptor is a protein complex that consists of this protein and interleukin 10 receptor, beta (IL10RB/CRFB4), a subunit also shared by the receptor complex for interleukin 10 (IL10). This gene and interleukin 28 receptor, alpha (IL28RA) form a cytokine receptor gene cluster in the chromosomal region 1p36.
Bleicher L, de Moura PR, Watanabe L, Colau D, Dumoutier L, Renauld JC, Polikarpov I (September 2008). "Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism". FEBS Letters. 582 (20): 2985–92. doi:10.1016/j.febslet.2008.07.046. PMID18675809. S2CID20952148.
Wu PW, Li J, Kodangattil SR, Luxenberg DP, Bennett F, Martino M, Collins M, Dunussi-Joannopoulos K, Gill DS, Wolfman NM, Fouser LA (October 2008). "IL-22R, IL-10R2, and IL-22BP binding sites are topologically juxtaposed on adjacent and overlapping surfaces of IL-22". Journal of Molecular Biology. 382 (5): 1168–83. doi:10.1016/j.jmb.2008.07.046. PMID18675824.
