MYCBP

In today's world, MYCBP is a topic that has captured the attention of people from all walks of life. The importance of MYCBP can be seen in its influence on society, politics, economics and culture. With the increasing relevance of MYCBP in our lives, it is crucial to understand its impact and the implications it has on our daily lives. In this article, we will take a closer look at MYCBP and explore its many facets, from its origin to its evolution over time. In addition, we will analyze how MYCBP has marked a before and after in different aspects of society and how it continues to shape our present and future.

Protein-coding gene in the species Homo sapiens

MYCBP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YY0
Identifiers
Aliases	MYCBP, AMY-1, MYC binding protein
External IDs	OMIM: 606535; MGI: 1891750; HomoloGene: 49312; GeneCards: MYCBP; OMA:MYCBP - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.3 Start 38,862,493 bp[1] End 38,873,368 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.2 Start 123,798,625 bp[2] End 123,806,062 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory zone of nasal mucosa gonad monocyte testicle mucosa of transverse colon right testis left testis rectum right uterine tube granulocyte Top expressed in genital tubercle zygote secondary oocyte tail of embryo olfactory epithelium Epithelium of choroid plexus primary oocyte seminiferous tubule yolk sac morula More reference expression data BioGPS n/a
Gene ontology Molecular function transcription coactivator activity protein binding Cellular component cytoplasm nucleus mitochondrion Biological process regulation of transcription, DNA-templated transcription, DNA-templated spermatogenesis positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26292 56309 Ensembl ENSG00000214114 ENSMUSG00000028647 UniProt Q99417 Q9EQS3 RefSeq (mRNA) NM_012333 NM_019660 RefSeq (protein) NP_036465 NP_062634 Location (UCSC) Chr 1: 38.86 – 38.87 Mb Chr 4: 123.8 – 123.81 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

C-Myc-binding protein is a protein that in humans is encoded by the MYCBP gene.^[5][6]

Function

The MYCBP gene encodes a protein that binds to the N-terminal region of MYC (MIM 190080) and stimulates the activation of E box-dependent transcription by MYC.^[6]

Interactions

MYCBP has been shown to interact with AKAP1,^[7][8] C3orf15^[7] and Myc.^[5]

References

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000214114 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000028647 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ ^{a b} Taira T, Maëda J, Onishi T, Kitaura H, Yoshida S, Kato H, Ikeda M, Tamai K, Iguchi-Ariga SM, Ariga H (Aug 1998). "AMY-1, a novel C-MYC binding protein that stimulates transcription activity of C-MYC". Genes to Cells. 3 (8): 549–65. doi:10.1046/j.1365-2443.1998.00206.x. PMID 9797456.
6. ^ ^{a b} "Entrez Gene: MYCBP c-myc binding protein".
7. ^ ^{a b} Yukitake H, Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H (Nov 2002). "AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex with AMY-1, A-kinase anchor protein 84, and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase". The Journal of Biological Chemistry. 277 (47): 45480–92. doi:10.1074/jbc.M206201200. PMID 12223483.
8. ^ Furusawa M, Ohnishi T, Taira T, Iguchi-Ariga SM, Ariga H (Sep 2001). "AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP-dependent protein kinase". The Journal of Biological Chemistry. 276 (39): 36647–51. doi:10.1074/jbc.M103885200. PMID 11483602.

Further reading

• Furusawa M, Ohnishi T, Taira T, Iguchi-Ariga SM, Ariga H (Sep 2001). "AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP-dependent protein kinase". The Journal of Biological Chemistry. 276 (39): 36647–51. doi:10.1074/jbc.M103885200. PMID 11483602.
• Yukitake H, Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H (Aug 2002). "AMAP-1, a novel testis-specific AMY-1-binding protein, is differentially expressed during the course of spermatogenesis". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1577 (1): 126–32. doi:10.1016/s0167-4781(02)00411-6. PMID 12151104.
• Yukitake H, Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H (Nov 2002). "AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex with AMY-1, A-kinase anchor protein 84, and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase". The Journal of Biological Chemistry. 277 (47): 45480–92. doi:10.1074/jbc.M206201200. PMID 12223483.
• Furusawa M, Taira T, Iguchi-Ariga SM, Ariga H (Dec 2002). "AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex". The Journal of Biological Chemistry. 277 (52): 50885–92. doi:10.1074/jbc.M206387200. PMID 12414807.
• Tomsig JL, Snyder SL, Creutz CE (Mar 2003). "Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif". The Journal of Biological Chemistry. 278 (12): 10048–54. doi:10.1074/jbc.M212632200. PMID 12522145.
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Ishizaki R, Shin HW, Iguchi-Ariga SM, Ariga H, Nakayama K (Aug 2006). "AMY-1 (associate of Myc-1) localization to the trans-Golgi network through interacting with BIG2, a guanine-nucleotide exchange factor for ADP-ribosylation factors". Genes to Cells. 11 (8): 949–59. doi:10.1111/j.1365-2443.2006.00991.x. PMID 16866877. S2CID 36364701.
• Sedoris KC, Thomas SD, Miller DM (Jul 2007). "c-myc promoter binding protein regulates the cellular response to an altered glucose concentration". Biochemistry. 46 (29): 8659–68. doi:10.1021/bi7003558. PMID 17595061.

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