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Mavacoxib

In this article, we will explore the impact of Mavacoxib on contemporary society. Mavacoxib has been the subject of interest and debate in various areas of knowledge, from social sciences to technology. Its influence has transcended geographical and cultural boundaries, and its relevance continues to constantly evolve. Throughout these pages, we will analyze the different aspects that make up the presence of Mavacoxib in our current reality, as well as its projection into the future. From its origin to its practical implications, we will delve into a deep analysis that seeks to shed light on a topic that is as relevant as it is unavoidable in contemporary times.

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Mavacoxib
Clinical data
Trade namesTrocoxil
AHFS/Drugs.comInternational Drug Names
ATCvet code
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
CompTox Dashboard (EPA)
ECHA InfoCard100.248.948 Edit this at Wikidata
Chemical and physical data
FormulaC16H11F4N3O2S
Molar mass385.34 g·mol−1
3D model (JSmol)
  • C1=CC(=CC=C1C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F)F
  • InChI=1S/C16H11F4N3O2S/c17-11-3-1-10(2-4-11)14-9-15(16(18,19)20)22-23(14)12-5-7-13(8-6-12)26(21,24)25/h1-9H,(H2,21,24,25)
  • Key:TTZNQDOUNXBMJV-UHFFFAOYSA-N

Mavacoxib (trade name Trocoxil) is a veterinary drug used to treat pain and inflammation in dogs with degenerative joint disease.[2] It acts as a COX-2 inhibitor.[3]

Mavacoxib, along with several other COX-2 selective inhibitors, including celecoxib, valdecoxib, and parecoxib, were discovered by a team at the Searle division of Monsanto led by John Talley.[4][5]

References

  1. ^ "Trocoxil EPAR". European Medicines Agency. 22 September 2008. Retrieved 26 June 2024.
  2. ^ European Public Assessment Report (EPAR): Trocoxil Archived 17 March 2018 at the Wayback Machine, European Medicines Agency
  3. ^ Cox SR, Lesman SP, Boucher JF, Krautmann MJ, Hummel BD, Savides M, et al. (October 2010). "The pharmacokinetics of mavacoxib, a long-acting COX-2 inhibitor, in young adult laboratory dogs". Journal of Veterinary Pharmacology and Therapeutics. 33 (5): 461–70. doi:10.1111/j.1365-2885.2010.01165.x. PMID 20840390.{{cite journal}}: CS1 maint: overridden setting (link)
  4. ^ Langreth R (23 June 2003). "The Chemical Cobbler". Forbes.{{cite news}}: CS1 maint: overridden setting (link)
  5. ^ "Dr. John Talley: 2001 St. Louis Awardee" (PDF). Chemical Bond. 52 (5). St. Louis Section, American Chemical Society: 2. May 2001. Archived from the original (PDF) on 15 April 2018.


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