Monocarboxylate transporter 3

The topic of Monocarboxylate transporter 3 has been the subject of debate and study for years, generating conflicting opinions and diverse theories. Since ancient times, Monocarboxylate transporter 3 has played a fundamental role in different aspects of human life, influencing the development of society, culture, politics and economy. Throughout history, Monocarboxylate transporter 3 has been the object of analysis and reflection, generating endless interpretations and discussions about its true meaning and its impact on today's world. In this article, we will explore the various facets of Monocarboxylate transporter 3, analyzing its importance and relevance today, as well as its influence in different areas of daily life.

Protein-coding gene in the species Homo sapiens

SLC16A8
Identifiers
Aliases	SLC16A8, MCT3, REMP, solute carrier family 16 member 8
External IDs	OMIM: 610409; MGI: 1929519; HomoloGene: 75006; GeneCards: SLC16A8; OMA:SLC16A8 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.1 Start 38,078,134 bp[1] End 38,084,184 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 79,135,214 bp[2] End 79,138,961 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in retinal pigment epithelium testicle nucleus accumbens sural nerve gonad C1 segment right uterine tube putamen Descending thoracic aorta ascending aorta Top expressed in retinal pigment epithelium choroid plexus of fourth ventricle Epithelium of choroid plexus gastrula embryo CA3 field ciliary body embryo saccule ectoderm More reference expression data BioGPS n/a
Gene ontology Molecular function symporter activity lactate transmembrane transporter activity monocarboxylic acid transmembrane transporter activity Cellular component integral component of plasma membrane plasma membrane membrane integral component of membrane Biological process monocarboxylic acid transport pyruvate metabolic process leukocyte migration lactate transport transmembrane transport lactate transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23539 57274 Ensembl ENSG00000100156 ENSMUSG00000032988 UniProt O95907 O35308 RefSeq (mRNA) NM_013356 NM_001394131 NM_020516 RefSeq (protein) NP_037488 NP_065262 Location (UCSC) Chr 22: 38.08 – 38.08 Mb Chr 15: 79.14 – 79.14 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Monocarboxylate transporter 3 (MCT3) also known as solute carrier family 16 member 8 is a protein that in humans is encoded by the SLC16A8 gene.^[5] MCT is a proton-coupled monocarboxylate transporter. It catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. It also functions as high-affinity pyruvate transporter.

Expression of SLC16A8 is confined to the retinal pigment epithelium and choroid plexus epithelia, where it is located on the basal membrane in contrast to MCT1 which is found on the apical membrane.

See also

• Monocarboxylate transporter

References

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000100156 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000032988 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Garcia CK, Goldstein JL, Pathak RK, Anderson RG, Brown MS (Mar 1994). "Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle". Cell. 76 (5): 865–73. doi:10.1016/0092-8674(94)90361-1. PMID 8124722. S2CID 22137883.

Further reading

• Yoon H, Donoso LA, Philp NJ (1999). "Cloning of the human monocarboxylate transporter MCT3 gene: localization to chromosome 22q12.3-q13.2". Genomics. 60 (3): 366–70. doi:10.1006/geno.1999.5926. PMID 10493836.
• Philp NJ, Wang D, Yoon H, Hjelmeland LM (2003). "Polarized expression of monocarboxylate transporters in human retinal pigment epithelium and ARPE-19 cells". Invest. Ophthalmol. Vis. Sci. 44 (4): 1716–21. doi:10.1167/iovs.02-0287. PMID 12657613.
• Wilson MC, Meredith D, Fox JE, Manoharan C, Davies AJ, Halestrap AP (2005). "Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70)". J. Biol. Chem. 280 (29): 27213–21. doi:10.1074/jbc.M411950200. PMID 15917240.
• Cori CF (1981). "The glucose-lactic acid cycle and gluconeogenesis". Curr. Top. Cell. Regul. Current Topics in Cellular Regulation. 18: 377–87. doi:10.1016/B978-0-12-152818-8.50028-1. ISBN 9780121528188. PMID 7273846.
• Halestrap AP, Meredith D (2004). "The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond". Pflügers Arch. 447 (5): 619–28. doi:10.1007/s00424-003-1067-2. PMID 12739169. S2CID 15498611.

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