In today's article we are going to delve into the fascinating world of Nephrotoxicity. We will explore its origins, its impact on society and the relevance it has had over time. Nephrotoxicity is a topic that never ceases to surprise us, its influence extends to different areas and has managed to capture the attention of people of all ages. Join us on this adventure as we unravel the secrets and curiosities that Nephrotoxicity has to offer us. Get ready to immerse yourself in a journey full of discoveries!
Nephrotoxicity is toxicity in the kidneys. It is a poisonous effect of some substances, both toxic chemicals and medications, on kidney function. There are various forms, and some drugs may affect kidney function in more than one way. Nephrotoxins are substances displaying nephrotoxicity.
Nephrotoxicity should not be confused with some medications predominantly excreted by the kidneys needing their dose adjusted for the decreased kidney function (e.g., heparin, lithium).
Main article : Acute interstitial nephritis
Drug-induced glomerular disease is not common but there are a few drugs that have been implicated. Glomerular lesions occur primarily through immune-mediated pathways rather than through direct drug toxicity.
Nephrotoxicity is usually monitored through a simple blood test. A decreased creatinine clearance indicates poor kidney function. In interventional radiology, a patient's creatinine clearance levels are all checked prior to a procedure.[citation needed]
Serum creatinine is another measure of kidney function, which may be more useful clinically when dealing with patients with early kidney disease. Normal creatinine level is between 80 - 120 μmol/L.[citation needed]
The word nephrotoxicity (/ˌnɛfroʊtɒkˈsɪsɪti/) uses combining forms of nephro- + tox- + -icity, yielding "kidney poisoning".[citation needed]