PCLKC

In this article, we are going to delve into the exciting world of PCLKC. From its origins to its current evolution, we will explore every relevant facet and aspect of PCLKC. It doesn't matter if you are an expert in the field or just starting to get interested in it, this article will provide you with a complete and detailed overview as well as up-to-date information about PCLKC. Through analysis, statistics and testimonies, we will discover its true impact and relevance in modern society. Get ready to immerse yourself in a journey of discovery and knowledge about PCLKC.

Protein-coding gene in the species Homo sapiens

CDHR2
Identifiers
Aliases	CDHR2, PCDH24, PCLKC, cadherin related family member 2, PCLCK
External IDs	MGI: 2687323; HomoloGene: 134510; GeneCards: CDHR2; OMA:CDHR2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q35.2 Start 176,542,511 bp[1] End 176,595,974 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 B1 Start 54,849,274 bp[2] End 54,884,475 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa mucosa of ileum duodenum mucosa of transverse colon rectum left testis right lobe of liver sperm right testis mucosa of sigmoid colon Top expressed in jejunum ileum duodenum epithelium of small intestine colon left colon Paneth cell yolk sac right kidney human kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding protein binding cell adhesion molecule binding Cellular component integral component of membrane spanning component of plasma membrane brush border membrane cell junction plasma membrane extracellular exosome apical plasma membrane brush border membrane cell projection microvillus membrane Biological process cell adhesion epithelial cell differentiation regulation of microvillus length negative regulation of cell growth involved in contact inhibition homophilic cell adhesion via plasma membrane adhesion molecules cell-cell adhesion mediated by cadherin intermicrovillar adhesion cell differentiation cell-cell adhesion Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54825 268663 Ensembl ENSG00000074276 ENSMUSG00000034918 UniProt Q9BYE9 E9Q7P9 RefSeq (mRNA) NM_001171976 NM_017675 NM_001033364 RefSeq (protein) NP_001165447 NP_060145 NP_001028536 Location (UCSC) Chr 5: 176.54 – 176.6 Mb Chr 13: 54.85 – 54.88 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protocadherin-24 is a protein that in humans is encoded by the PCDH24 gene.^[5][6][7]

Interactions

PCLKC has been shown to interact with MAST2.^[6]

References

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000074276 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000034918 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Suzuki ST (Dec 2000). "Recent progress in protocadherin research". Exp Cell Res. 261 (1): 13–8. doi:10.1006/excr.2000.5039. PMID 11082270.
6. ^ ^{a b} Okazaki N, Takahashi N, Kojima S, Masuho Y, Koga H (Jul 2002). "Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation". Carcinogenesis. 23 (7): 1139–48. doi:10.1093/carcin/23.7.1139. PMID 12117771.
7. ^ "Entrez Gene: PCLKC protocadherin LKC".

Further reading

• Yang LY, Wang W, Peng JX, et al. (2005). "Differentially expressed genes between solitary large hepatocellular carcinoma and nodular hepatocellular carcinoma". World J. Gastroenterol. 10 (24): 3569–73. doi:10.3748/wjg.v10.i24.3569. PMC 4611994. PMID 15534908.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

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