Tremorine

In today's article we are going to delve into the exciting world of Tremorine. From its origins to its relevance today, we will explore every relevant aspect of Tremorine in detail to provide you with a complete overview of this topic. Throughout the next few lines, we will discover the main key points, the latest trends and expert opinions on Tremorine. With this content, we hope to give you a deep and up-to-date understanding of Tremorine, so that you can enrich your knowledge and make more informed decisions on this topic. Get ready to immerse yourself in a fascinating universe full of nuances!

Tremorine
Clinical data
ATC code
  • none
Identifiers
  • 1-(4-pyrrolidin-1-ylbut-2-ynyl)pyrrolidine
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC12H20N2
Molar mass192.306 g·mol−1
3D model (JSmol)
  • C2CCCN2CC#CCN1CCCC1
  • InChI=1S/C12H20N2/c1-2-8-13(7-1)11-5-6-12-14-9-3-4-10-14/h1-4,7-12H2
  • Key:JSUAJTLKVREZHV-UHFFFAOYSA-N

Tremorine is a drug which is used in scientific research to produce tremor in animals. This is used for the development of drugs for the treatment of Parkinson's disease, as tremor is a major symptom which is treated by anti-Parkinson's drugs. Beta blockers are also effective in counteracting the effects of tremorine.

History

Tremorine was first reported by Everett et al. in 1956-57.

References

  1. ^ Trautner EM, Gershon S (May 1959). "Use of tremorine for screening anti-parkinsonian drugs". Nature. 183 (4673): 1462–3. Bibcode:1959Natur.183.1462T. doi:10.1038/1831462a0. PMID 13657170. S2CID 4173699.
  2. ^ Friedman AH, Aylesworth RJ, Friedman G (September 1963). "Tremorine: Its Effect on Amines of the Central Nervous System". Science. 141 (3586): 1188–90. Bibcode:1963Sci...141.1188F. doi:10.1126/science.141.3586.1188. PMID 14043364. S2CID 37472968.
  3. ^ Menon M, Clark WG, Aures D (1971). "Effect of tremorine, oxotremorine and decaborane on brain histamine levels in rats". Pharmacological Research Communications. 3 (4): 345–350. doi:10.1016/0031-6989(71)90005-1.
  4. ^ Shinozaki H, Hirate K, Ishida M (May 1985). "Further studies on quantification of drug-induced tremor in mice: effects of antitremorgenic agents on tremor frequency". Experimental Neurology. 88 (2): 303–15. doi:10.1016/0014-4886(85)90193-1. PMID 3987859. S2CID 7607662.
  5. ^ Morais LC, Quintans-Júnior LJ, Franco CI, Almeida JR, Almeida RN (December 2004). "Antiparkinsonian-like effects of Plumbago scandens on tremorine-induced tremors methodology". Pharmacology, Biochemistry, and Behavior. 79 (4): 745–9. doi:10.1016/j.pbb.2004.10.004. PMID 15582683. S2CID 28371865.
  6. ^ Paul V (1986). "The role of adrenergic mechanism in tremorine-induced tremors in rats: antitremor effect of beta-adrenoceptor antagonists". Indian Journal of Physiology and Pharmacology. 30 (4): 307–12. PMID 2883120.
  7. ^ Everett, Guy M. (1956). "Tremor produced by drugs". Nature v. 177(4522), p. 1238. ("In the routine screening of drugs in mice, we have found only ten out of ten thousand compounds which produce sustained tremor. One of these, 1-4 dipyrrolidino-2-butyne, 'Tremorine', in doses of 5–20 mgm./kgm. produces tremor, salivation, meiosis, etc."
  8. ^ Everett G.M., Blockus L.E. and Sheppard I.M. (1956). "Tremor induced by tremorine and its antagonism by anti-Parkinson drugs." Science v. 124, p.79.
  9. ^ Everett G.M., Blockus L.E., Sheppard I.M. and Toman J.E.P. (1956), Federation Proceedings v. 15, p. 420.
  10. ^ Blockus, L. E. and Everett, G. M. (January 1957). "Tremor producing drug 1,4 di-pyrrolidino-2-butyne (Tremorine)", Federation Proceedings v. 16(1), p. 283.

See also

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