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Submission declined on 24 June 2025 by Dan arndt (talk).
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Despite initial promise, nanoparticle-based drug delivery has not yet delivered transformative results in preventing restenosis. challenges include poor targeting efficiency, rapid clearance by the mononuclear phagocyte system and complex vascular microenvironments that limit drug penetration. moreover, the inflammatory milieu following angioplasty may alter nanoparticle behavior in unpredictable ways. while research continues into surface modifications and bio responsive designs, translation to clinical use remains distant.
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