User:Nrm48/sandbox
The issue of User:Nrm48/sandbox is a topic that has generated great interest and controversy in recent times. With different approaches and perspectives, User:Nrm48/sandbox has been the subject of debate and research in various areas of knowledge. From its impact on society to its implications at the individual level, User:Nrm48/sandbox has captured the attention of academics, specialists and ordinary people. In this article, we will explore different aspects related to User:Nrm48/sandbox, analyzing its relevance and unraveling its possible consequences. Additionally, we will examine how User:Nrm48/sandbox has shaped and will continue to shape the current landscape, offering a comprehensive view of this important topic.
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Magee-Womens Research Institute (MWRI) is home to University of Pittsburgh researchers and UPMC Magee-Womens physician-scientists engaged in research that spans reproductive biology and diseases impacting the health of women. Thematic areas include the formation of germ cells and embryos, childhood and adolescent congenital and acquired diseases, reproduction, pregnancy and parturition, menopause, aging, bone and brain health. Unique to MWRI is the multidimensionality of its research, which spans approaches from molecular and cellular biology to epidemiology and community engagement. In addition to studying women and their families, scientists use synthetic biology to model organisms to tackle high impact research questions.
MWRI's researchers use a variety of basic, translational, and clinical investigative tools that support our central mission to:
- Advance knowledge in the field of reproductive biology and medicine
- Translate discoveries into improved health for women and families
- Train the next generation of scholars in the reproductive sciences
- Partner with local, regional, and national communities on the role of science in health and wellness, and foster community investment and involvement in women's health research
MWRI was established in 1992 as an independent research institute and the research arm of the Department of Obstetrics, Gynecology & Reproductive Sciences (OBGYN&RS) of the University of Pittsburgh. Initially located in a 50,000-sq. ft. remodeled building on Craft Avenue, across the street from UPMC Magee-Womens Hospital, MWRI's research building expanded in 2007 to a total of 125,000 sq. ft. of modern laboratory facilities, core space, and conference rooms.
MWRI seamlessly integrates basic, translational, and clinical faculty researchers from the University of Pittsburgh's Department of OBGYN&RS, as well as affiliate members from other departments at the University of Pittsburgh School of Medicine (including Anesthesiology, Medicine, Pathology, Pediatrics, Pharmacology and Chemical Biology, Psychiatry, Radiology, Surgery and Urology), School of Public Health (Epidemiology, Behavioral & Community Health Sciences, Health Policy and Management, and Environmental and Occupational Health), Pharmacy (Pharmaceutical Sciences), Engineering (Bioengineering), Nursing (Health Promotion & Development), and Education (Health & Human Development).
MWRI's collaborative approach to research, affiliation with the University of Pittsburgh and UPMC Magee-Womens Hospital, and location immediately adjacent to Magee's large clinical patient care center further buttress the strengths of our individual research programs.
Whereas laboratory-based research is housed primarily within the research building on Craft Avenue, patient-based research is conducted at UPMC Magee-Womens Hospital and other UPMC clinical facilities located throughout the Pittsburgh academic community. This structure fosters unique opportunities for collaboration among our investigators and a rich environment for our training programs.
RESEARCH COLLABORATIONS AND PARTNERSHIPS
As we embark on the next phase of research exploration, collaborations with partners in industry, biotech, and start-ups will be crucial in the advancement of women's health initiatives.
BENCHTOP BASICS AND CORE SUPPORT
Researchers at MWRI have expertise performing basic research across all areas of our focus, with a wide range of assays and techniques that include:
- Computational modeling
- Bioinformatics
- 3D printing
- Animal translational research
- Mechanobiology
- Tissue regeneration/tissue engineering
- DNA/RNA sequencing
- Gene expression
- Genomic Editing
- RNAi screening
- Array comparative genomic
- hybridization (CGH)
- High throughput multi-omics
- Flow cytometry/Fluorescent Activated Sorting
- Activated Cellular Sorting
- Confocal imaging and
- histology preparation
CLINICAL COLLECTIONS
From a clinical sample collection perspective, MWRI sits directly across the street from UPMC Magee-Womens Hospital. Outside of the clinical operations in Pittsburgh, PA, MWRI also features clinical operational space within UPMC Magee-Womens Hamot in Erie, PA. MWRI has access to over 40 hospitals for clinical sites in Western PA, NY, and WV. With numerous clinical collection suites located in the hospital, MWRI researchers can collect, process, and store the following types of biospecimens in quick and efficient fashion:
- Urine
- Electrocardiography
- Glucose Tolerance Testing
- Pap smears
- Tissue Collections
- Cervical and Vaginal
- Tissue biopsy
- Phlebotomy (adult and infant)
- Pharmacokinetic sampling
- Cervical/Vaginal/Rectal fluids
- Rectal tissues via sigmoidoscopy
- Placental/Umbilical tissue
- Imaging
- Obstetrical and gynecological
- ultrasound
- MRI
CLINICAL ASSAY AND PRODUCT DEVELOPMENT
With the number of clinical trials that occur within MWRI, a vast number of clinical assays have been performed in-house by MWRI researchers, which include:
- Cervical/Vaginal/Rectal explant challenge
- Pharmacodynamic testing
- Vaginal microbiome analysis
- HPV subtyping and testing
- Histological processing
- Analytical services
- Pre-formulation
- Drug interactions/PK
- Formulation Development
- Tech transfer & Scale up
- Mechanical testing
- Organ bath assay
- Hormone levels
GRANT WRITING AND PUBLICATION SUPPORT
At MWRI, we have highly experienced individuals in the grant writing and publication spaces. Since 2015, our faculty and support researchers have submitted over 1,500 grants for federal and industry funding, varying from R01, R21, SBIR, DOD, and many others. In that same period, we've seen over 2,400 of our research studies make it to publication. Magee-Womens Foundation also works to raise money for research and patient care.