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XAP044

In today's world, XAP044 has become a topic of great importance and interest to a wide range of people. From experts in the field to the general public, XAP044 has captured everyone's attention due to its relevance in today's society. In this article, we will explore in detail the different facets of XAP044, from its impact on everyday life to its influence on culture and politics. Through comprehensive analysis, we hope to provide a clear and complete view of XAP044, allowing our readers to better understand its importance and role in today's world.

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XAP044
Identifiers
  • 7-hydroxy-3-(4-iodophenoxy)-4H-chromen-4-one
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
Chemical and physical data
FormulaC15H9IO4
Molar mass380.137 g·mol−1
3D model (JSmol)
  • C1=CC(=CC=C1OC2=COC3=C(C2=O)C=CC(=C3)O)I
  • InChI=1S/C15H9IO4/c16-9-1-4-11(5-2-9)20-14-8-19-13-7-10(17)3-6-12(13)15(14)18/h1-8,17H
  • Key:XXZKJJYWINSUMJ-UHFFFAOYSA-N

XAP044 is a drug which acts as a potent and selective antagonist of the metabotropic glutamate receptor 7 (mGluR7). It inhibits long-term potentiation in the amygdala and inhibits responses associated with stress and anxiety in animal models,[1] as well as being used to study the role of mGluR7 in various other processes.[2][3][4]

References

  1. ^ Gee CE, Peterlik D, Neuhäuser C, Bouhelal R, Kaupmann K, Laue G, et al. (April 2014). "Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior". The Journal of Biological Chemistry. 289 (16): 10975–10987. doi:10.1074/jbc.M113.542654. PMC 4036238. PMID 24596089.
  2. ^ Hajasova Z, Canestrelli C, Acher F, Noble F, Marie N (March 2018). "Role of mGlu7 receptor in morphine rewarding effects is uncovered by a novel orthosteric agonist". Neuropharmacology. 131: 424–430. doi:10.1016/j.neuropharm.2018.01.002. PMID 29307544. S2CID 3391450.
  3. ^ Gryksa K, Mittmann L, Bauer A, Peterlik D, Flor PJ, Uschold-Schmidt N, Bosch OJ (January 2020). "Metabotropic glutamate receptor subtype 7 controls maternal care, maternal motivation and maternal aggression in mice". Genes, Brain and Behavior. 19 (1) e12627. doi:10.1111/gbb.12627. PMID 31793148. S2CID 208609219.
  4. ^ Estrela KA, Senninger L, Arndt J, Kabas M, Schmid F, Dillmann L, et al. (June 2022). "Blocking Metabotropic Glutamate Receptor Subtype 7 via the Venus Flytrap Domain Promotes a Chronic Stress-Resilient Phenotype in Mice". Cells. 11 (11): 1817. doi:10.3390/cells11111817. PMC 9180111. PMID 35681512.
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