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Alexander Zverev defeated Dominic Thiem in the final, 6–4, 6–4 to win the men's singles tennis title at the 2018 Madrid Open. He did not lose a set en route to the title, and did not have his serve broken throughout the entire tournament.
Rafael Nadal was the defending champion, but lost to Thiem in the quarterfinals in a rematch of the previous year's final. His defeat ended a 50-set winning streak on clay, the longest single-surface set-winning streak in the Open Era.