Adapalene/benzoyl peroxide

In this article we want to explore the fascinating world of Adapalene/benzoyl peroxide. From its origins to its relevance today, Adapalene/benzoyl peroxide has been a topic of interest to many people around the world. Throughout history, Adapalene/benzoyl peroxide has played a crucial role in various aspects of society, culture and technology. Furthermore, Adapalene/benzoyl peroxide has been the subject of debate and controversy, which has contributed to its complexity and continued evolution. Through this article, we hope to shed light on this exciting topic and provide a deeper insight into Adapalene/benzoyl peroxide and its impact on the world we live in.

Adapalene/benzoyl peroxide
Combination of
AdapaleneRetinoid
Benzoyl peroxidePeroxide
Clinical data
Trade namesEpiduo, Epiduo Forte
Routes of
administration		Topical
ATC code
Legal status
Legal status
  • US: ℞-only
  • In general: ℞ (Prescription only)
Identifiers
CAS Number
KEGG
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Adapalene/benzoyl peroxide, sold under the brand name Epiduo among others, is a fixed-dose combination medication for the treatment of severe acne vulgaris. It consists of a combination of adapalene and benzoyl peroxide in a topical gel formulation.

It is available as a generic medication.

Medical uses

Adapalene/benzoyl peroxide is indicated for the topical treatment of acne vulgaris.

Side effects

Commonly reported side effects include the following:

Research

Meta-analysis of clinical trials has shown this combined therapy to be more effective than either of its ingredients by themselves.

The use of adapalene/benzoyl peroxide in combination with oral antibiotics (lymecycline) has been studied; the combination was well tolerated and showed an improved success rate compared to those receiving only antibiotics (47.6% vs. 33.7%, P = 0.002).

References

  1. ^ a b c d e "Epiduo- adapalene and benzoyl peroxide gel". DailyMed. 21 February 2018. Retrieved 15 May 2022.
  2. ^ a b c d e "Epiduo Forte- adapalene and benzoyl peroxide gel". DailyMed. 27 April 2022. Retrieved 15 May 2022.
  3. ^ "Competitive Generic Therapy Approvals". U.S. Food and Drug Administration (FDA). 29 June 2023. Archived from the original on 29 June 2023. Retrieved 29 June 2023.
  4. ^ Tan J, Gollnick HP, Loesche C, Ma YM, Gold LS (August 2011). "Synergistic efficacy of adapalene 0.1%-benzoyl peroxide 2.5% in the treatment of 3855 acne vulgaris patients". The Journal of Dermatological Treatment. 22 (4): 197–205. doi:10.3109/09546631003681094. PMID 20666678. S2CID 34631151.
  5. ^ Dréno B, Kaufmann R, Talarico S, Torres Lozada V, Rodríguez-Castellanos MA, Gómez-Flores M, et al. (August 2011). "Combination therapy with adapalene-benzoyl peroxide and oral lymecycline in the treatment of moderate to severe acne vulgaris: a multicentre, randomized, double-blind controlled study". The British Journal of Dermatology. 165 (2): 383–90. doi:10.1111/j.1365-2133.2011.10374.x. PMID 21495995. S2CID 21793660.

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