Dimethylstilbestrol
In this article about Dimethylstilbestrol, we will explore different aspects related to this topic that is so relevant today. Throughout the next few lines, we will analyze its origins, its evolution over time and its impact on society. We will also examine the different perspectives and opinions on Dimethylstilbestrol, as well as its relevance in the present and future. This article seeks to provide an overview and complete overview of Dimethylstilbestrol, with the aim of giving readers a deeper understanding of this topic and its implications in various areas.
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| Other names | DMS; (Ε)-α,α'-Dimethyl-4,4'-stilbenediol |
| Drug class | Nonsteroidal estrogen |
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| Formula | C16H16O2 |
| Molar mass | 240.302 g·mol−1 |
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Dimethylstilbestrol (DMS) is a nonsteroidal estrogen of the stilbestrol group related to diethylstilbestrol which was never marketed.[1][2][3][4][5]: 213 It is a so-called "weak", "impeded", or "short-acting" estrogen similarly to estriol and meso-butoestrol.[6][7][8][9] The affinity of DMS for the ER was reported as about 10% of that of estradiol.[10] For comparison, diethylstilbestrol had 140% of the affinity of estradiol for the ER.[10]
The endometrial proliferation dose of DMS in women is 20 mg.[5]: 212–213 A single 12 mg intramuscular injection of DMS has a duration of approximately 12 days in humans.[5]
References
- ^ Pincus G (3 September 2013). "Blastocyst Development and Implantation". The Control of Fertility. Elsevier. pp. 126–. ISBN 978-1-4832-7088-3.
- ^ Emmens CW, Martin L (5 December 2016). "Anti-Estrogens". In Dorfman RI (ed.). Steroidal Activity in Experimental Animals and Man. Elsevier Science. pp. 83–. ISBN 978-1-4832-7299-3.
- ^ Hilf R, Wittliff JL (27 November 2013). "Mechanisms of Action of Estrogens". In Sartorelli AC, Johns DG (eds.). Antineoplastic and Immunosuppressive Agents. Springer Science & Business Media. pp. 110–. ISBN 978-3-642-65806-8.
- ^ Horwitz KB, McGuire WL (14 December 2013). "Antiestrogens: Mechanism of Action and Effects in Breast Cancer". In McGuire W (ed.). Experimental Biology. Springer Science & Business Media. pp. 169–. ISBN 978-1-4757-4673-0.
- ^ a b c Knörr K, Beller FK, Lauritzen C (17 April 2013). "Prinzipien der Hormonbehandlung: Die wichtigsten hormonalen Behandlungsmethoden". Lehrbuch der Gynäkologie. Springer-Verlag. ISBN 978-3-662-00942-0.
- ^ Katzenellenbogen BS, Iwamoto HS, Heiman DF, Lan NC, Katzenellenbogen JA (1978). "Stilbestrols and stilbestrol derivatives: estrogenic potency and temporal relationships between estrogen receptor binding and uterine growth". Molecular and Cellular Endocrinology. 10 (1): 103–113. doi:10.1016/0303-7207(78)90063-1. PMID 564791. S2CID 45882988.
- ^ Martin L (January 1969). "Dimethylstilbestrol and 16-oxo-estradiol: anti-estrogens or estrogens?". Steroids. 13 (1): 1–10. doi:10.1016/s0039-128x(69)80055-3. PMID 5764482.
- ^ Emmens CW, Cox RI, Martin L (July 1959). "Oestrogen inhibitors of the stilboestrol series". The Journal of Endocrinology. 18 (4): 372–380. doi:10.1677/joe.0.0180372. PMID 13820198.
- ^ Emmens CW, Cox RI (September 1958). "Dimethylstilboestrol as an oestrogen inhibitor". The Journal of Endocrinology. 17 (3): 265–271. doi:10.1677/joe.0.0170265. PMID 13587831.
- ^ a b Jordan VC, Lieberman ME (September 1984). "Estrogen-stimulated prolactin synthesis in vitro. Classification of agonist, partial agonist, and antagonist actions based on structure". Molecular Pharmacology. 26 (2): 279–285. CiteSeerX 10.1.1.1064.9508. PMID 6541293.
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