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Fosdevirine

The topic of Fosdevirine is of great importance in today's society. It has generated a wide debate and has become a focal point of discussion in different areas. The impact of Fosdevirine on our lives is undeniable, and its relevance has been recognized by experts in the field. Throughout history, Fosdevirine has played an important role, shaping the way we live and interact with our environment. In this article, we will explore the different aspects of Fosdevirine and its influence today. From its origins to its impact on today's society, we will immerse ourselves in a deep analysis that will allow us to better understand the importance of Fosdevirine in our lives.

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Fosdevirine
Clinical data
Other namesGSK2248761; GSK2248761A; IDX-12899; IDX-899
ATC code
  • None
Identifiers
  • 5-Chloro-3--5-methylphenyl]-methoxyphosphoryl]-1H-indole-2-carboxamide
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
Chemical and physical data
FormulaC20H17ClN3O3P
Molar mass413.80 g·mol−1
3D model (JSmol)
  • CC1=CC(=CC(=C1)/C=C/C#N)(=O)(C2=C(NC3=C2C=C(C=C3)Cl)C(=O)N)OC
  • InChI=1S/C20H17ClN3O3P/c1-12-8-13(4-3-7-22)10-15(9-12)28(26,27-2)19-16-11-14(21)5-6-17(16)24-18(19)20(23)25/h3-6,8-11,24H,1-2H3,(H2,23,25)/b4-3+/t28-/m1/s1
  • Key:CGBYTKOSZYQOPV-ASSBYYIWSA-N

Fosdevirine is an experimental antiviral agent of the non-nucleoside reverse transcriptase inhibitor class that was studied for potential use in the treatment of HIV-AIDS.[1][2]

It was discovered by Idenix Pharmaceuticals and was being developed by GlaxoSmithKline and ViiV Healthcare, but it has now been discontinued[3][4] due to unexpected side effects.[5]

References

  1. ^ Dousson C, Alexandre FR, Amador A, Bonaric S, Bot S, Caillet C, et al. (March 2016). "Discovery of the Aryl-phospho-indole IDX899, a Highly Potent Anti-HIV Non-nucleoside Reverse Transcriptase Inhibitor". Journal of Medicinal Chemistry. 59 (5): 1891–8. doi:10.1021/acs.jmedchem.5b01430. PMID 26804933.
  2. ^ "Fosdevirine". AIDSinfo. U.S. National Library of Medicine, U.S. Department of Health and Human Services. Archived from the original on 2019-08-11. Retrieved 2018-08-14.
  3. ^ "Fosdevirine". Adis Insight. Springer Nature Switzerland AG. Highest Development Phases: Discontinued, HIV-1 infections
  4. ^ "Fosdevirine". MedKoo Biosciences. GSK2248761 is no longer in clinical development.
  5. ^ Margolis DA, Eron JJ, DeJesus E, White S, Wannamaker P, Stancil B, Johnson M (2013). "Unexpected finding of delayed-onset seizures in HIV-positive, treatment-experienced subjects in the Phase IIb evaluation of fosdevirine (GSK2248761)". Antiviral Therapy. 19 (1): 69–78. doi:10.3851/IMP2689. PMID 24158593. S2CID 6147197.
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