Intergenic lcrF RNA thermometer
In this article we are going to explore the topic of Intergenic lcrF RNA thermometer, a topic that has captured the attention of many people in recent years. Intergenic lcrF RNA thermometer is a multi-faceted topic that has been the subject of study and debate for a long time. Throughout history, Intergenic lcrF RNA thermometer has played a crucial role in different aspects of human life, from science to culture, politics and society in general. In this article, we will dive into the different dimensions of Intergenic lcrF RNA thermometer and try to shed light on its implications and impact on the world today. Through a detailed and exhaustive analysis, we will try to offer a complete view of Intergenic lcrF RNA thermometer and its relevance today.
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| LcrF intergenic thermometer | |
|---|---|
 Predicted secondary structure and sequence conservation of LcrF intergenic thermometer | |
| Identifiers | |
| Rfam | RF02704 |
| Other data | |
| Domain | Bacteria |
| GO | GO:0045975,GO:0009266 |
| SO | SO:0005836 |
| PDB structures | PDBe |
RNA thermometers regulate gene expression in response to temperature allowing pathogens like Yersinia to switch on silent genes after entering the host organism. Usually, RNA thermometers are located in the 5'UTR, but an intergenic RNA thermometer was found in Yersinia pseudotuberculosis. The LcrF RNA thermometer together with the thermo-labile YmoA protein activates synthesis of the most crucial virulence activator LcrF (VirF). The RNA thermosensor sequence is 100% identical in all human pathogenic Yersinia species.[1][2]
References
- ^ Böhme K, Steinmann R, Kortmann J, Seekircher S, Heroven AK, Berger E, Pisano F, Thiermann T, Wolf-Watz H, Narberhaus F, Dersch P (February 2012). "Concerted actions of a thermo-labile regulator and a unique intergenic RNA thermosensor control Yersinia virulence". PLOS Pathogens. 8 (2) e1002518. doi:10.1371/journal.ppat.1002518. PMC 3280987. PMID 22359501.
- ^ Schwiesow L, Lam H, Dersch P, Auerbuch V (December 2015). "Yersinia Type III Secretion System Master Regulator LcrF". Journal of Bacteriology. 198 (4): 604–614. doi:10.1128/JB.00686-15. PMC 4751813. PMID 26644429.
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