KIF3C

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Protein-coding gene in the species Homo sapiens

KIF3C
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3B6V
Identifiers
Aliases	KIF3C, kinesin family member 3C
External IDs	OMIM: 602845; MGI: 107979; HomoloGene: 55640; GeneCards: KIF3C; OMA:KIF3C - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p23.3 Start 25,926,598 bp[1] End 25,982,749 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 A1.1|12 1.77 cM Start 3,415,132 bp[2] End 3,456,494 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence Brodmann area 46 pons prefrontal cortex orbitofrontal cortex frontal pole right frontal lobe superior frontal gyrus dorsolateral prefrontal cortex postcentral gyrus Top expressed in dentate gyrus of hippocampal formation granule cell medial dorsal nucleus superior frontal gyrus dorsal tegmental nucleus ventral tegmental area medial geniculate nucleus lateral geniculate nucleus medial vestibular nucleus pontine nuclei cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function microtubule binding microtubule motor activity nucleotide binding ATPase activity cytoskeletal motor activity ATP binding Cellular component cytoplasm cytosol ciliary tip microtubule cytoskeleton kinesin complex cilium Biological process microtubule-based movement antigen processing and presentation of exogenous peptide antigen via MHC class II organelle transport along microtubule retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum intraciliary transport involved in cilium assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3797 16570 Ensembl ENSG00000084731 ENSMUSG00000020668 UniProt O14782 O35066 RefSeq (mRNA) NM_002254 NM_008445 RefSeq (protein) NP_002245 NP_032471 Location (UCSC) Chr 2: 25.93 – 25.98 Mb Chr 12: 3.42 – 3.46 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Kinesin-like protein KIF3C is a protein that in humans is encoded by the KIF3C gene.^[5][6] It is part of the kinesin family of motor proteins.

References

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000084731 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000020668 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Sardella M, Navone F, Rocchi M, Rubartelli A, Viggiano L, Vignali G, Consalez GG, Sitia R, Cabibbo A (Apr 1998). "KIF3C, a novel member of the kinesin superfamily: sequence, expression, and mapping to human chromosome 2 at 2p23". Genomics. 47 (3): 405–8. doi:10.1006/geno.1997.5123. PMID 9480755.
6. ^ "Entrez Gene: KIF3C kinesin family member 3C".

Further reading

• Davidovic L, Jaglin XH, Lepagnol-Bestel AM, et al. (2008). "The fragile X mental retardation protein is a molecular adaptor between the neurospecific KIF3C kinesin and dendritic RNA granules". Hum. Mol. Genet. 16 (24): 3047–58. doi:10.1093/hmg/ddm263. PMID 17881655.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Elenich LA, Nandi D, Kent AE, et al. (1999). "The complete primary structure of mouse 20S proteasomes". Immunogenetics. 49 (10): 835–42. doi:10.1007/s002510050562. PMID 10436176. S2CID 20977116.
• Muresan V, Abramson T, Lyass A, et al. (1998). "KIF3C and KIF3A form a novel neuronal heteromeric kinesin that associates with membrane vesicles". Mol. Biol. Cell. 9 (3): 637–52. doi:10.1091/mbc.9.3.637. PMC 25292. PMID 9487132.
• Yang Z, Goldstein LS (1998). "Characterization of the KIF3C neural kinesin-like motor from mouse". Mol. Biol. Cell. 9 (2): 249–61. doi:10.1091/mbc.9.2.249. PMC 25248. PMID 9450952.
• Telford EA, Wightman P, Leek J, et al. (1998). "cDNA cloning, genomic organization, and chromosomal localization of a novel human gene that encodes a kinesin-related protein highly similar to mouse Kif3C". Biochem. Biophys. Res. Commun. 242 (2): 407–12. doi:10.1006/bbrc.1997.7977. PMID 9446808.

External links

• Overview of all the structural information available in the PDB for UniProt: O14782 (Human Kinesin-like protein KIF3C) at the PDBe-KB.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

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