SPTBN5

In today's world, SPTBN5 is a topic that generates interest and debate in different areas of society. Whether due to its historical relevance, its impact today or its influence in the future, SPTBN5 is a topic that does not go unnoticed. From different perspectives and approaches, we have sought to understand and analyze SPTBN5 to understand its importance and consequences. In this article, we will explore different aspects related to SPTBN5, from its origin to its relevance today, with the aim of providing a comprehensive view on this topic.

Protein-coding gene in the species Homo sapiens

SPTBN5
Identifiers
Aliases	SPTBN5, BSPECV, HUBSPECV, HUSPECV, spectrin beta, non-erythrocytic 5
External IDs	OMIM: 605916; MGI: 2685200; HomoloGene: 41150; GeneCards: SPTBN5; OMA:SPTBN5 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q15.1 Start 41,848,146 bp[1] End 41,894,053 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 E5 Start 119,871,974 bp[2] End 119,916,159 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve cerebellar hemisphere right hemisphere of cerebellum testicle apex of heart retinal pigment epithelium skin of abdomen granulocyte left ventricle right lobe of thyroid gland Top expressed in esophagus muscle of thigh hypothalamus muscle tissue skeletal muscle tissue quadriceps femoris muscle lip striatum of neuraxis zone of skin islet of Langerhans More reference expression data BioGPS n/a
Gene ontology Molecular function dynactin binding protein self-association kinesin binding myosin tail binding actin binding dynein intermediate chain binding spectrin binding Cellular component cytoplasm cytosol spectrin membrane photoreceptor connecting cilium photoreceptor disc membrane cytoskeleton microtubule organizing center filamentous actin Biological process Golgi organization MAPK cascade axon guidance endoplasmic reticulum to Golgi vesicle-mediated transport actin filament capping lysosomal transport protein homooligomerization actin cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51332 640524 Ensembl ENSG00000137877 ENSMUSG00000074899 UniProt Q9NRC6 n/a RefSeq (mRNA) NM_016642 NM_001370938 RefSeq (protein) NP_057726 n/a Location (UCSC) Chr 15: 41.85 – 41.89 Mb Chr 2: 119.87 – 119.92 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Spectrin, beta, non-erythrocytic 5 also known as SPTBN5 is a protein that in humans is encoded by the SPTBN5 gene.^[5] SPTBN5 belongs to the spectrin family of cytoskeletal proteins.

Structure and function

SPTBN5 contains the following domains:^[5]

• actin-binding domain
• membrane-association domain-1
• self-association domain
• C-terminal pleckstrin homology domain.

Based on these structural features it is thought that SPTBN5 is likely to form heterodimers and oligomers with alpha-spectrin and to interact directly with cellular membranes.^[5]

SPTBN5 is highly expressed in embryoid bodies.^[6]

References

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000137877 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000074899 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ ^{a b c} Stabach PR, Morrow JS (July 2000). "Identification and characterization of beta V spectrin, a mammalian ortholog of Drosophila beta H spectrin". J. Biol. Chem. 275 (28): 21385–95. doi:10.1074/jbc.C000159200. PMID 10764729.
6. ^ Chaerkady R, Kerr CL, Marimuthu A, Kelkar DS, Kashyap MK, Gucek M, Gearhart JD, Pandey A (January 2009). "Temporal analysis of neural differentiation using quantitative proteomics". J. Proteome Res. 8 (3): 1315–26. doi:10.1021/pr8006667. PMC 2693473. PMID 19173612.

Further reading

• Odell AF, Van Helden DF, Scott JL (2008). "The spectrin cytoskeleton influences the surface expression and activation of human transient receptor potential channel 4 channels". J. Biol. Chem. 283 (7): 4395–407. doi:10.1074/jbc.M709729200. hdl:1959.13/39937. PMID 18048348.
• Oguri M, Kato K, Yokoi K, et al. (2010). "Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals". Am. J. Hypertens. 23 (1): 70–7. doi:10.1038/ajh.2009.190. PMID 19851296.
• Shoeman RL, Hartig R, Hauses C, Traub P (2002). "Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease". Cell Biol. Int. 26 (6): 529–39. doi:10.1006/cbir.2002.0895. PMID 12119179. S2CID 39778155.
• Chardin P, Camonis JH, Gale NW, et al. (1993). "Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2". Science. 260 (5112): 1338–43. Bibcode:1993Sci...260.1338C. doi:10.1126/science.8493579. PMID 8493579.

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