The importance of KLRB1 in our society is undeniable. Over time, KLRB1 has become a determining factor in various aspects of daily life. From its impact on the economy to its influence on culture, KLRB1 plays a crucial role in shaping today's world. In this article, we will explore in depth the relevance of KLRB1 and its role in different areas, as well as the implications it has for the future. Through detailed analysis, we will seek to better understand the importance of KLRB1 in this ever-changing world.
Killer cell lectin-like receptor subfamily B, member 1, also known as KLRB1, NKR-P1A or CD161 (cluster of differentiation 161), is a human gene.[5]
Function
Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein, NKR-P1A or CD161, is classified as a type II membrane protein because it has an external C terminus.[5] NKR-P1A, the receptor encoded by the KLRB1 gene, recognizes Lectin Like Transcript-1 (LLT1) as a functional ligand. Its engagement by NKR-P1 leads to clustering of the latter on the NK cell surface mediating an inhibitory signalling.[6]
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