PCTK2

Today, PCTK2 is a topic that has gained unprecedented relevance in modern society. From its impact on people's daily lives to its influence on economic, cultural and political spheres, PCTK2 has become a focal point of discussion and debate. With the advancement of technology and globalization, PCTK2 has acquired an importance that transcends borders and affects people of all ages and social conditions. In this article, we will explore the various facets of PCTK2 and analyze its impact on the world today.

Protein-coding gene in the species Homo sapiens

CDK17
Identifiers
Aliases	CDK17, PCTAIRE2, PCTK2, cyclin-dependent kinase 17, cyclin dependent kinase 17
External IDs	OMIM: 603440; MGI: 97517; HomoloGene: 55666; GeneCards: CDK17; OMA:CDK17 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q23.1 Start 96,278,261 bp[1] End 96,400,480 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C2 Start 93,160,875 bp[2] End 93,267,071 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum Region I of hippocampus proper Brodmann area 23 external globus pallidus Achilles tendon visceral pleura postcentral gyrus vena cava superior frontal gyrus middle temporal gyrus Top expressed in olfactory tubercle Region I of hippocampus proper piriform cortex nucleus accumbens subiculum primary motor cortex temporal lobe amygdala prefrontal cortex anterior amygdaloid area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding protein binding ATP binding kinase activity cyclin-dependent protein serine/threonine kinase activity protein serine/threonine kinase activity Cellular component nucleus cytoplasm Biological process protein phosphorylation phosphorylation regulation of cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5128 237459 Ensembl ENSG00000059758 ENSMUSG00000020015 UniProt Q00537 Q8K0D0 RefSeq (mRNA) NM_001170464 NM_002595 NM_146239 RefSeq (protein) NP_001163935 NP_002586 NP_666351 Location (UCSC) Chr 12: 96.28 – 96.4 Mb Chr 10: 93.16 – 93.27 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein kinase PCTAIRE-2 is an enzyme that in humans is encoded by the CDK17 gene.^[5][6]

The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to rat protein which is thought to play a role in terminally differentiated neurons.^[6]

References

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000059758 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000020015 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Hirose T, Tamaru T, Okumura N, Nagai K, Okada M (Dec 1997). "PCTAIRE 2, a Cdc2-related serine/threonine kinase, is predominantly expressed in terminally differentiated neurons". Eur J Biochem. 249 (2): 481–8. doi:10.1111/j.1432-1033.1997.t01-1-00481.x. PMID 9370357.
6. ^ ^{a b} "Entrez Gene: PCTK2 PCTAIRE protein kinase 2".

Further reading

• Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai LH (1992). "A family of human cdc2-related protein kinases". EMBO J. 11 (8): 2909–17. doi:10.1002/j.1460-2075.1992.tb05360.x. PMC 556772. PMID 1639063.
• Hirose T, Kawabuchi M, Tamaru T, Okumura N, Nagai K, Okada M (2000). "Identification of tudor repeat associator with PCTAIRE 2 (Trap). A novel protein that interacts with the N-terminal domain of PCTAIRE 2 in rat brain". Eur. J. Biochem. 267 (7): 2113–21. doi:10.1046/j.1432-1327.2000.01218.x. PMID 10727952.
• Yamochi T, Nishimoto I, Okuda T, Matsuoka M (2001). "ik3-1/Cables is associated with Trap and Pctaire2". Biochem. Biophys. Res. Commun. 286 (5): 1045–50. Bibcode:2001BBRC..286.1045Y. doi:10.1006/bbrc.2001.5493. PMID 11527406.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J (2003). "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene. 22 (50): 8102–16. doi:10.1038/sj.onc.1206972. PMID 14603251. S2CID 10536264.
• Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Wissing J, Jänsch L, Nimtz M, Dieterich G, Hornberger R, Keri G, Wehland J, Daub H (2007). "Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry". Mol. Cell. Proteomics. 6 (3): 537–47. doi:10.1074/mcp.T600062-MCP200. hdl:10033/19756. PMID 17192257.

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