Tu banner alternativo

FGIN-143

Nowadays, FGIN-143 is a topic that has captured the attention of many people around the world. Whether due to its impact on society, its relevance in history, or its influence on culture, FGIN-143 has managed to position itself as a point of interest for a wide variety of audiences. In this article, we will thoroughly explore the different aspects of FGIN-143, analyzing its importance and implications in various contexts. From its origin to its current evolution, FGIN-143 invites us to reflect on its meaning and relevance in our daily lives. Join us as we delve into the world of FGIN-143 and uncover the intricacies that make it such a compelling topic.

Tu banner alternativo
FGIN-143
Identifiers
  • 2--N,N-dihexylacetamide
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC28H36Cl2N2O
Molar mass487.51 g·mol−1
3D model (JSmol)
  • c3cc(Cl)ccc3-c2c1ccc(Cl)cc1c2CC(=O)N(CCCCCC)CCCCCC
  • InChI=1S/C28H36Cl2N2O/c1-3-5-7-9-17-32(18-10-8-6-4-2)27(33)20-25-24-19-23(30)15-16-26(24)31-28(25)21-11-13-22(29)14-12-21/h11-16,19,31H,3-10,17-18,20H2,1-2H3
  • Key:XTZUPNNVXIMWAR-UHFFFAOYSA-N
  (verify)

FGIN-1-43 is an anxiolytic drug which acts as a selective agonist at the peripheral benzodiazepine receptor, also known as the mitochondrial 18 kDa translocator protein or TSPO. It is thought to produce anxiolytic effects by stimulating steroidogenesis of neuroactive steroids such as allopregnanolone, and is several times more potent than the related drug FGIN-127.[1][2][3][4]

References

  1. ^ Romeo E, Auta J, Kozikowski AP, Ma D, Papadopoulos V, Puia G, et al. (September 1992). "2-Aryl-3-indoleacetamides (FGIN-1): a new class of potent and specific ligands for the mitochondrial DBI receptor (MDR)". The Journal of Pharmacology and Experimental Therapeutics. 262 (3): 971–8. PMID 1326631.
  2. ^ Kozikowski AP, Ma D, Brewer J, Sun S, Costa E, Romeo E, Guidotti A (October 1993). "Chemistry, binding affinities, and behavioral properties of a new class of "antineophobic" mitochondrial DBI receptor complex (mDRC) ligands". Journal of Medicinal Chemistry. 36 (20): 2908–20. doi:10.1021/jm00072a010. PMID 8411007.
  3. ^ Costa E, Auta J, Guidotti A, Korneyev A, Romeo E (June 1994). "The pharmacology of neurosteroidogenesis". The Journal of Steroid Biochemistry and Molecular Biology. 49 (4–6): 385–9. doi:10.1016/0960-0760(94)90284-4. PMID 8043504. S2CID 33492066.
  4. ^ Guillon J, Boulouard M, Lelong V, Dallemagne P, Rault S, Jarry C (November 2001). "Synthesis and preliminary behavioural evaluation in mice of new 3-aryl-3-pyrrol-1-ylpropanamides, analogues of FGIN-1-27 and FGIN-1-43". The Journal of Pharmacy and Pharmacology. 53 (11): 1561–8. doi:10.1211/0022357011777945. PMID 11732760. S2CID 11838769.
Stub icon

This article about an anxiolytic is a stub. You can help Wikipedia by expanding it.

Wikious
Boobota
Sagapedia