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Ro60-0213

Why is Ro60-0213 so important nowadays? Ro60-0213 has captured the attention of millions of people around the world, generating controversy and debate in all areas. Since its appearance, Ro60-0213 has been the subject of analysis and discussion in various fields, from science and technology to politics and popular culture. In this article we will explore the impact that Ro60-0213 has had on today's society and how its presence has shaped the way we think and act. Additionally, we will examine the relevance of Ro60-0213 in a constantly changing world and how its influence continues to be noticeable in our daily lives.

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Ro60-0213
Identifiers
  • (S)-1-(7-methoxyindenopyrrol-1(4H)-yl)propan-2-amine
CAS Number
PubChem CID
ChemSpider
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC15H18N2O
Molar mass242.322 g·mol−1
3D model (JSmol)
  • C(Cn1ccc2c1-c3cc(ccc3C2)OC)N
  • InChI=1S/C15H18N2O/c1-10(16)9-17-6-5-12-7-11-3-4-13(18-2)8-14(11)15(12)17/h3-6,8,10H,7,9,16H2,1-2H3/t10-/m0/s1
  • Key:OTCPUISFVUWAGR-JTQLQIEISA-N
  (verify)

Ro60-0213 (Org 35032) is a drug developed by Hoffmann–La Roche, which acts as a potent and selective agonist for the 5-HT2C serotonin receptor, with more than 100x selectivity over other closely related serotonin receptor subtypes, and little or no affinity at other receptors. It was developed as a potential antidepressant,[1] but was discontinued from clinical development at an early stage due to toxicity concerns.[2] However the high selectivity of Ro60-0213 for 5-HT2C makes it of continued interest for research into serotonin receptors.[3]

See also

References

  1. ^ Leysen D, Kelder J (1998). "Ligands for the 5-HT2C receptor as potential antidepressants and anxiolytics". Trends in Drug Research II, Proceedings of the 11th Noordwijkerhout-Camerino Symposium. Pharmacochemistry Library. Vol. 29. pp. 49–61. doi:10.1016/S0165-7208(98)80044-5. ISBN 9780444826336.
  2. ^ Albertini S, Bös M, Gocke E, Kirchner S, Muster W, Wichmann J (July 1998). "Suppression of mutagenic activity of a series of 5HT2c receptor agonists by the incorporation of a gem-dimethyl group: SAR using the Ames test and a DNA unwinding assay". Mutagenesis. 13 (4): 397–403. doi:10.1093/mutage/13.4.397. PMID 9717178.
  3. ^ Shimada I, Maeno K, Kazuta K, Kubota H, Kimizuka T, Kimura Y, et al. (February 2008). "Synthesis and structure-activity relationships of a series of substituted 2-(1H-furoindazol-1-yl)ethylamine derivatives as 5-HT2C receptor agonists". Bioorganic & Medicinal Chemistry. 16 (4): 1966–82. doi:10.1016/j.bmc.2007.10.100. PMID 18035544.
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