In the world of Pinazepam, there is a long tradition of study, debate and exploration. Since ancient times, Pinazepam has been an object of fascination and curiosity, generating endless theories, discoveries and advances in various fields. Currently, Pinazepam continues to be a relevant topic of interest to society, since its influence extends to different aspects of daily life. In this article, we will delve into the exciting world of Pinazepam, analyzing its impact and relevance today, as well as exploring its possible implications for the future.
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Other names | 9-chloro-6-phenyl-2-prop-2-ynyl-2,5-diazabicycloundeca-5,8,10,12-tetraen-3-one |
AHFS/Drugs.com | International Drug Names |
Routes of administration | Oral |
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Pharmacokinetic data | |
Metabolism | Hepatic |
Excretion | Renal |
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ECHA InfoCard | 100.052.650 |
Chemical and physical data | |
Formula | C18H13ClN2O |
Molar mass | 308.77 g·mol−1 |
3D model (JSmol) | |
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Pinazepam (marketed under the brand name Domar and Duna) is a benzodiazepine drug. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties.
Pinazepam and its metabolite N-desmethyldiazepam are transferred to the developing fetus in utero, but the plasma drug level in the mother is usually significantly higher than in the fetus.
Pinazepam differs from other benzodiazepines in that it has a propargyl group at the N-1 position of the benzodiazepine structure. It is less toxic than diazepam and in animal studies it appears to produce anxiolytic and anti-agitation properties with limited hypnotic and motor coordination impairing properties. Pinazepam is rapidly absorbed after oral administration. The main active metabolites of pinazepam are depropargylpinazepam (N-desmethyldiazepam, nordazepam) and oxazepam. In humans pinazepam acts as a pure anxiolytic agent in that it does not possess to any significant degree the other pharmacological characteristics of benzodiazepines. Its lack of intellectual, motor and hypnotic impairing effects makes it more appropriate than other benzodiazepines for day time use. The elimination half-life is longer in the elderly.