Keratinocyte growth factor
Today, Keratinocyte growth factor is a highly relevant topic that captures the attention of people of all ages and backgrounds. Its impact on society and daily life is undeniable, and it generates endless opinions, debates and discussions. It is a topic that arouses curiosity and fascination, but also entails challenges and controversies. In this article, we will explore in detail the different facets of Keratinocyte growth factor, analyzing its influence in various areas, its evolution over time, and the role it plays in people's lives today.
The keratinocyte growth factor (KGF), also known as FGF7, is a growth factor present in the epithelialization-phase of wound healing. In this phase, keratinocytes are covering the wound, forming the epithelium.
KGF is a small signaling molecule that binds to fibroblast growth factor receptor 2b (FGFR2b). For signalling to occur, a dimer is required between two FGF:FGFR complexes that is linked together by a molecule of heparin.
There are 23 known FGFs, and 4 FGF receptors. FGF:FGFR binding is complex and regulated by a variety of mechanisms in a tissue specific manner.
FGF10 is also known as "keratinocyte growth factor 2".
See also
References
- ^ Rotolo S, Ceccarelli S, Romano F, Frati L, Marchese C, Angeloni A (2008). Maas S (ed.). "Silencing of Keratinocyte Growth Factor Receptor Restores 5-Fluorouracil and Tamoxifen Efficacy on Responsive Cancer Cells". PLOS ONE. 3 (6): e2528. Bibcode:2008PLoSO...3.2528R. doi:10.1371/journal.pone.0002528. PMC 2424182. PMID 18575591.
- ^ "iHOP - Information Hyperlinked over Proteins [ FGF10 ]". Archived from the original on 2012-02-14.
External links
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