Today, Semaxanib is a topic that has captured the attention of millions of people around the world. With its impact on society, economy and culture, Semaxanib is a phenomenon that deserves to be analyzed and understood in depth. Throughout history, Semaxanib has played a crucial role in the evolution of humanity, influencing decision-making, the way we relate to each other, and the way we see the world around us. In this article, we will explore different aspects related to Semaxanib, from its origin to its influence in the present, including its future potential. Through this analysis, we hope to shed light on a topic that continues to have a significant impact on our lives.
In February 2002, Pharmacia, the then-parent of Sugen, prematurely ended phase III clinical trials of semaxinib in the treatment of advanced colorectal cancer due to discouraging results. Other studies, at earlier phases, have since been conducted. However, due to the prospect of next-generation tyrosine kinase inhibitors and the inefficacy of semaxanib in clinic trials, further development of the drug has been discontinued. A related compound, SU11248 (sunitinib), was further developed by Sugen and subsequently by Pfizer, and received FDA approval for treatment of renal carcinoma in January 2006.
When combined with chronic exposure to hypoxia, SU5416 induces severe pulmonary hypertension in mice and rats. This property has been exploited to develop a series of useful, though controversial, rodent models of pulmonary arterial hypertension, the first and best characterized being the Sugen/Hypoxia (SuHx) mouse model.
References
^World Health Organization (2001). "International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 85". WHO Drug Information. 15 (2). "Full text"(PDF). Archived from the original(PDF) on 2007-03-16. (244 KiB)
^Lockhart AC, Cropp GF, Berlin JD, Donnelly E, Schumaker RD, Schaaf LJ, Hande KR, Fleischer AC, Hannah AL, Rothenberg ML (April 2006). "Phase I/pilot study of SU5416 (semaxinib) in combination with irinotecan/bolus 5-FU/LV (IFL) in patients with metastatic colorectal cancer". American Journal of Clinical Oncology. 29 (2): 109–15. doi:10.1097/01.coc.0000199882.53545.ac. PMID16601426. S2CID26566099.