Nowadays, 2,5-Dimethoxy-4-bromoamphetamine is a topic of great relevance in today's society. There are many aspects that revolve around 2,5-Dimethoxy-4-bromoamphetamine, from its impact on the economy to its influence on culture and politics. Since ancient times, 2,5-Dimethoxy-4-bromoamphetamine has been the subject of debate and study, and has generated a large number of theories and approaches that have tried to understand its importance and nature. In this article, we will delve into the world of 2,5-Dimethoxy-4-bromoamphetamine, exploring its different facets and analyzing its role in contemporary society.
The full name of the chemical is 2,5-dimethoxy-4-bromoamphetamine. DOB has a stereocenter and R-(−)-DOB is the eutomer. This is an important finding as it is suggestive that it is targeting different receptors relative to most other phenethylamines (e.g. MDMA) where the R-isomer serves as the distomer. The toxicity of DOB is not fully known, although high doses may cause serious vasoconstriction of the extremities. DOB is one of the most potent compounds in PiHKAL; while the active dose is similar to that of DOI, another psychedelic amphetamine, DOB has been shown to have a higher efficacy in triggering downstream effects mediated by 5-HT2 receptors, making it likely to be slightly more dangerous than DOI in overdose, due to greater vasoconstrictive action. Omission of the amphetamine related α-methyl leads to 2C-B, a compound that possesses a lower affinity for the 5-HT2A receptor and is a weaker receptor agonist which results in drastically reduced vasoconstriction.[citation needed]
It has been suggested that DOB is a prodrug metabolized in the lungs.
Excessively high doses of this hallucinogen may cause diffuse arterial spasm. The vasospasm responded readily to intra-arterial and intravenous vasodilators, such as tolazoline.
Legal status
Internationally DOB is a Schedule I substance under the Convention on Psychotropic Substances and the drug is legal only for medical, industrial or scientific purposes.
Canada
Listed as a Schedule 1 as it is an analogue of amphetamine.
Australia
DOB is considered a Schedule 9 prohibited substance in Australia under the Poisons Standard (February 2017). A Schedule 9 substance is a substance which may be abused or misused, the manufacture, possession, sale or use of which should be prohibited by law except when required for medical or scientific research, or for analytical, teaching or training purposes with approval of Commonwealth and/or State or Territory Health Authorities.
Russia
Schedule I, possession of at least 10 mg is a criminal offence.
† References for all endogenous human TAAR1 ligands are provided at List of trace amines
‡ References for synthetic TAAR1 agonists can be found at TAAR1 or in the associated compound articles. For TAAR2 and TAAR5 agonists and inverse agonists, see TAAR for references.