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Mexedrone

In today's article, we will explore the fascinating world of Mexedrone. From its historical origin to its relevance in today's society, we will delve into a journey through the highlights of Mexedrone. In addition, we will examine in depth its impact in different areas, from culture to technology. Through various perspectives and approaches, we aim to shed light on this topic that is so relevant today. Get ready to discover everything you need to know about Mexedrone and immerse yourself in a comprehensive analysis of its importance in the contemporary world.

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Mexedrone
Legal status
Legal status
Identifiers
  • 3-Methoxy-2-(methylamino)-1-(4-methylphenyl)propan-1-one
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC12H17NO2
Molar mass207.273 g·mol−1
3D model (JSmol)
  • Cc1ccc(cc1)C(=O)C(COC)NC
  • InChI=1S/C12H17NO2/c1-9-4-6-10(7-5-9)12(14)11(13-2)8-15-3/h4-7,11,13H,8H2,1-3H3
  • Key:JHGDCSPZKQLBOP-UHFFFAOYSA-N

Mexedrone (also known as 4-MMC-MeO) is a stimulant and an entactogen drug of the cathinone class that has been sold online as a designer drug.[1][2][3][4] It is the alpha-methoxy derivative of Mephedrone.

Pharmacology

Mexedrone acts as a weak serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI) with IC50 values of 5,289 nM, 8,869 nM, and 6,844 nM, respectively, as well as a weak serotonin releasing agent (SRA) with an EC50 value of 2,525 nM.[5]

Mexedrone is illegal in Sweden as of January 26, 2016[6] as well as Japan as of August 24, 2016.[7]

See also

References

  1. ^ "Mexedrone". New Synthetic Drug Database.
  2. ^ Qian Z, Jia W, Li T, Liu C, Hua Z (February 2017). "Identification and analytical characterization of four synthetic cathinone derivatives iso-4-BMC, β-TH-naphyrone, mexedrone, and 4-MDMC". Drug Testing and Analysis. 9 (2): 274–281. doi:10.1002/dta.1983. PMID 27352812.
  3. ^ Kuś P, Rojkiewicz M, Kusz J, Książek M, Sochanik A (14 May 2019). "Spectroscopic characterization and crystal structures of four hydrochloride cathinones: N-ethyl-2-amino-1-phenylhexan-1-one (hexen, NEH), N-methyl-2-amino-1-(4-methylphenyl)-3-methoxypropan-1-one (mexedrone), N-ethyl-2-amino-1-(3,4-methylenedioxyphenyl)pentan-1-one (ephylone) and N-butyl-2-amino-1-(4-chlorophenyl)propan-1-one (4-chlorobutylcathinone)". Forensic Toxicology. 37 (2): 456–464. doi:10.1007/s11419-019-00477-y. hdl:20.500.12128/9638.
  4. ^ Roberts L, Ford L, Patel N, Vale JA, Bradberry SM (March 2017). "11 analytically confirmed cases of mexedrone use among polydrug users". Clinical Toxicology. 55 (3): 181–186. doi:10.1080/15563650.2016.1271424. PMID 28075189. S2CID 33220365.
  5. ^ McLaughlin G, Morris N, Kavanagh PV, Power JD, Dowling G, Twamley B, et al. (March 2017). "Synthesis, characterization and monoamine transporter activity of the new psychoactive substance mexedrone and its N-methoxy positional isomer, N-methoxymephedrone". Drug Testing and Analysis. 9 (3): 358–368. doi:10.1002/dta.2053. PMC 5336524. PMID 27524685.
  6. ^ "31 nya ämnen kan klassas som narkotika eller hälsofarlig vara" (in Swedish). Folkhälsomyndigheten. November 2015.
  7. ^ "指定薬物一覧" (PDF) (in Japanese). Ministry of Health, Labour and Welfare.
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