ALX-1393

In this article, we will explore the impact of ALX-1393 in various areas of contemporary society. ALX-1393 has been the subject of study and controversy for decades, and its influence ranges from popular culture to world politics. Through the analysis of ALX-1393, we will be able to better understand how it has shaped the way we live, think, and relate to the world around us. From its origins to its future projection, ALX-1393 continues to be a topic of debate and reflection, and this article aims to examine the different perspectives that exist around this phenomenon.

ALX-1393
Names
IUPAC name
(2S)-2-Amino-3-propanoic acid
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
  • InChI=1S/C23H22FNO4/c24-18-10-6-9-17(13-18)22(29-15-20(25)23(26)27)19-11-4-5-12-21(19)28-14-16-7-2-1-3-8-16/h1-13,20,22H,14-15,25H2,(H,26,27)/t20-,22?/m0/s1
    Key: ADUSZEGHFWRTQS-AIBWNMTMSA-N
  • C1=CC=C(C=C1)COC2=CC=CC=C2C(C3=CC(=CC=C3)F)OCC(C(=O)O)N
Properties
C23H22FNO4
Molar mass 395.430 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa).

ALX-1393 is a glycine reuptake inhibitor.

Pharmacodynamics

ALX-1393 works by inhibiting the action of GLYT2. This causes elevated levels of glycine, an inhibitory neurotransmitter.

Potential uses

ALX-1393 has been shown to have potential as an analgesic. This is thought to be due to the elevated glycine levels reducing the transmission of the pain signals.

Tests have shown that it was able to help reduce cancer pain in a potent way.

References

  1. ^ "(2S)-2-amino-3-{[2-(benzyloxy)phenyl](3-fluorophenyl)methoxy}propanoic acid".
  2. ^ Eckle, V.-S.; Antkowiak, B. (2013-12-03). "ALX 1393 inhibits spontaneous network activity by inducing glycinergic tonic currents in the spinal ventral horn". Neuroscience. 253: 165–171. doi:10.1016/j.neuroscience.2013.08.042. ISSN 1873-7544. PMID 23994185. S2CID 30039776.
  3. ^ Benito-Muñoz, Cristina; Perona, Almudena; Felipe, Raquel; Pérez-Siles, Gonzalo; Núñez, Enrique; Aragón, Carmen; López-Corcuera, Beatriz (2021-06-02). "Structural Determinants of the Neuronal Glycine Transporter 2 for the Selective Inhibitors ALX1393 and ORG25543". ACS Chemical Neuroscience. 12 (11): 1860–1872. doi:10.1021/acschemneuro.0c00602. ISSN 1948-7193. PMC 8691691. PMID 34003005.
  4. ^ Motoyama, Naoyo; Morita, Katsuya; Shiraishi, Seiji; Kitayama, Tomoya; Kanematsu, Takashi; Uezono, Yasuhito; Dohi, Toshihiro (October 2014). "Relief of cancer pain by glycine transporter inhibitors". Anesthesia and Analgesia. 119 (4): 988–995. doi:10.1213/ANE.0000000000000388. ISSN 1526-7598. PMID 25076101.


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