In today's world, Chlorobutanol is a widely discussed topic that has gained relevance in different areas of society. From its impact on the economy to its influence on interpersonal relationships, Chlorobutanol has generated endless debates and reflections. As time has progressed, opinions and perspectives on Chlorobutanol have evolved, giving rise to a wide range of approaches and analyzes on the matter. In this article, we will explore the different dimensions of Chlorobutanol and analyze its importance in the current context, with the aim of providing a comprehensive vision of this very relevant topic.
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Names | |||
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Preferred IUPAC name
1,1,1-Trichloro-2-methylpropan-2-ol | |||
Other names
1,1,1-Trichloro-2-methyl-2-propanol; Chlorbutol; Chloreton; Chloretone; Chlortran; Trichloro-tert-butyl alcohol; 1,1,1-Trichloro-tert-butyl alcohol; 2-(Trichloromethyl)propan-2-ol; tert-Trichlorobutyl alcohol; Trichloro-tert-butanol; Trichlorisobutylalcohol; 2,2,2-Trichloro-1,1-dimethylethanol
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Identifiers | |||
3D model (JSmol)
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ChEMBL | |||
ChemSpider | |||
ECHA InfoCard | 100.000.288 | ||
EC Number |
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KEGG | |||
PubChem CID
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UNII | |||
CompTox Dashboard (EPA)
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Properties | |||
C4H7Cl3O | |||
Molar mass | 177.45 g·mol−1 | ||
Appearance | White solid | ||
Odor | Camphor | ||
Melting point | 95–99 °C (203–210 °F; 368–372 K) | ||
Boiling point | 167 °C (333 °F; 440 K) | ||
Slightly soluble | |||
Solubility in acetone | Soluble | ||
Pharmacology | |||
A04AD04 (WHO) | |||
Hazards | |||
Occupational safety and health (OHS/OSH): | |||
Main hazards
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Xn | ||
NFPA 704 (fire diamond) | |||
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa).
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Chlorobutanol (trichloro-2-methyl-2-propanol) is an organic compound with the formula CCl3C(OH)(CH3)2. The compound is an example of a chlorohydrin. The compound is a preservative, sedative, hypnotic and weak local anesthetic similar in nature to chloral hydrate. It has antibacterial and antifungal properties. Chlorobutanol is typically used at a concentration of 0.5% where it lends long term stability to multi-ingredient formulations. However, it retains antimicrobial activity at 0.05% in water. Chlorobutanol has been used in anesthesia and euthanasia of invertebrates and fishes. It is a white, volatile solid with a camphor-like odor.
Chlorobutanol was first synthesized in 1881 by the German chemist Conrad Willgerodt (1841–1930).
Chlorobutanol is formed by the reaction of chloroform and acetone in the presence of potassium or sodium hydroxide. It may be purified by sublimation or recrystallisation.
Chlorobutanol has proven effective at stimulating parthenogenesis in sea urchin eggs up to the pluteus stage, possibly by increasing irritability to cause stimulation. For the eggs of the fish Oryzias latipes, however, chlorobutanol only acted as an anesthetic.
It is an anesthetic with effects related to isoflurane and halothane.
Chlorobutanol is toxic to the liver, a skin irritant and a severe eye irritant.