In today's world, Laudanosine has become a topic of great relevance and interest to a wide spectrum of people. From business owners and professionals to academics and leisure lovers, Laudanosine has captured the attention of millions of individuals around the world. Whether for its social impact, its historical relevance, or its importance in the modern world, Laudanosine is a topic that deserves to be explored in depth. In this article, we will delve into the different aspects of Laudanosine, analyzing its meaning, its evolution over time and its influence in various areas of society.
Laudanosine or N-methyltetrahydropapaverine is a recognized metabolite of atracurium and cisatracurium. Laudanosine decreases the seizure threshold, and thus it can induce seizures if present at sufficient threshold concentrations; however such concentrations are unlikely to be produced consequent to chemodegradable metabolism of clinically administered doses of cisatracurium or atracurium.
Laudanosine also occurs naturally in minute amounts (0.1%) in opium, from which it was first isolated in 1871. Partial dehydrogenation of laudanosine will lead to papaverine, the alkaloid found in the opium poppy plant (Papaver somniferum).
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