Sinomenine

In the world of Sinomenine, there are endless aspects and details worth exploring. From its origins to its impact today, Sinomenine has captured the attention of millions of people around the world. Whether through history, science, music, art or any other field, Sinomenine continues to be a topic of interest to people of all ages and cultures. In this article, we will delve into the different aspects of Sinomenine, exploring its many facets and analyzing its influence on today's society. From its beginnings to the present, Sinomenine has left an indelible mark on history and will surely remain relevant for future generations.

Chemical compound

Sinomenine

Clinical data
Other names	Cocculine
ATC code	none
Identifiers
IUPAC name (9α,13α,14α)-4-Hydroxy-3,7-dimethoxy-17-methyl-7,8-didehydromorphinan-6-one
CAS Number	115-53-7 Y
PubChem CID	5459308
ChemSpider	10179905 N
UNII	63LT81K70N
ChEMBL	ChEMBL248095 N
ECHA InfoCard	100.003.722
Chemical and physical data
Formula	C19H23NO4
Molar mass	329.396 g·mol−1
3D model (JSmol)	Interactive image
SMILES CN1CC23CC(=O)C(=C21CC4=C3C(=C(C=C4)OC)O)OC
InChI InChI=1S/C19H23NO4/c1-20-7-6-19-10-14(21)16(24-3)9-12(19)13(20)8-11-4-5-15(23-2)18(22)17(11)19/h4-5,9,12-13,22H,6-8,10H2,1-3H3/t12-,13+,19-/m1/s1 N Key:INYYVPJSBIVGPH-QHRIQVFBSA-N N
NY (what is this?)  (verify)

Sinomenine or cocculine is an alkaloid found in the root of the climbing plant Sinomenium acutum which is native to Japan and China. The plant is traditionally used in herbal medicine in these countries for rheumatism and arthritis. However, its analgesic action against other kinds of pain is limited. Sinomenine is a morphinan derivative, related to opioids such as levorphanol and the non-opioid cough suppressant dextromethorphan. Its anti-rheumatic effects are thought to be primarily mediated via release of histamine, but other effects such as inhibition of prostaglandin, leukotriene and nitric oxide synthesis may also be involved.

See also

• Hasubanan
• Oreobeiline

References

1. ^ Zhao ZZ, Liang ZT, Zhou H, Jiang ZH, Liu ZQ, Wong YF, et al. (January 2005). "Quantification of sinomenine in caulis sinomenii collected from different growing regions and wholesale herbal markets by a modified HPLC method". Biological & Pharmaceutical Bulletin. 28 (1): 105–9. doi:10.1248/bpb.28.105. PMID 15635172.
2. ^ Yamasaki H (February 1976). "Pharmacology of sinomenine, an anti-rheumatic alkaloid from Sinomenium acutum". Acta Medica Okayama. 30 (1): 1–20. PMID 61710.
3. ^ Liu L, Riese J, Resch K, Kaever V (November 1994). "Impairment of macrophage eicosanoid and nitric oxide production by an alkaloid from Sinomenium acutum". Arzneimittel-Forschung. 44 (11): 1223–6. PMID 7848335.