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Phenyltoloxamine

In this article we will explore the fascinating world of Phenyltoloxamine, a topic that has captured the attention of millions of people around the world. From its historical origins to its impact on modern society, Phenyltoloxamine has left an indelible mark on popular culture. Throughout these pages, we will delve into its different facets, discovering its relevance in fields as diverse as science, art, technology and politics. With exclusive interviews, in-depth analysis and interesting facts, this article will take you on an enriching journey through everything Phenyltoloxamine has to offer. Get ready to immerse yourself in an exciting universe full of surprises, because in these lines, Phenyltoloxamine will be the undisputed protagonist.

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Phenyltoloxamine
Clinical data
AHFS/Drugs.comInternational Drug Names
Pregnancy
category
  • C (US)
Routes of
administration		Oral
ATC code
  • None
Identifiers
  • 2-(2-Benzylphenoxy)-N,N-dimethylethanamine
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.001.935 Edit this at Wikidata
Chemical and physical data
FormulaC17H21NO
Molar mass255.361 g·mol−1
3D model (JSmol)
  • O(c1ccccc1Cc2ccccc2)CCN(C)C
  • InChI=1S/C17H21NO/c1-18(2)12-13-19-17-11-7-6-10-16(17)14-15-8-4-3-5-9-15/h3-11H,12-14H2,1-2H3 checkY
  • Key:IZRPKIZLIFYYKR-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Phenyltoloxamine is an antihistamine with sedative and analgesic effects.[1][2] It is available in combination with other drugs such as paracetamol (acetominophen).[3]

Common use

Phenyltoloxamine is widely used in preparations as an enhancing agent for some analgesics and antitussives (acetaminophen, dihydrocodeine, codeine, hydrocodone). It is widely used in certain parts of the world as cough suppressant usually with codeine, and sometimes by itself or in addition to dextromethorphan as it, like diphenhydramine, possesses antitussive action of its own and is particularly useful in semi-productive coughs because of its moderate drying action.

Phenyltoloxamine is used in combination with paracetamol, aspirin and other salicylates and other drugs in proprietary preparations available over the counter for backache, muscle strains and similar conditions.

Adverse effects

Common adverse effects are those associated with most anticholinergics, with effects being more pronounced in children and the elderly.[medical citation needed]

Availability

Though it is rare in several Western countries[which?], phenyltoloxamine is widely used on the global scale, particularly in the developing world.

In the past it was not a controlled substance. It was taken off the market but is available OTC again in the US by some[which?] pharmaceutical companies. Some preparations contain opiates such as codeine or hydrocodone and are controlled. When used in preparations with acetaminophen it is generally over the counter.

Phenyltoloxamine combinations are sold under wide variety of preparations, brand names and dosages around the world:

  • Aceta-Gesic, Ed-Flex, Dologesic, Duraxin, Flextra-650, Novagesic, Pain-gesic, Phenylgesic - North America
  • Codipront - Europe/South America
  • Codivis - Israel

See also

References

  1. ^ "Phenyltoloxamine". Drugbank.
  2. ^ Cronk GA, Naumann DE (May 1955). "Phenyltoloxamine--dosage, toxicity, and clinical application". New York State Journal of Medicine. 55 (10): 1465–7. PMID 14370508.
  3. ^ "Phenyltoloxamine-acetaminophen oral". WebMD.
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