Pyrinuron

This article will address Pyrinuron, a topic that has gained great relevance in recent times. Pyrinuron has captured the attention of experts and the general public due to its impact and relevance in different aspects of society. Throughout history, Pyrinuron has been the subject of study and debate, which has generated various interpretations and approaches to this topic. In this sense, it is important to analyze Pyrinuron from multiple perspectives in order to understand its scope and impact in various areas. That is why this article is presented, with the aim of providing a comprehensive and updated view on Pyrinuron, providing relevant information for the reader interested in delving deeper into this fascinating topic.

Pyrinuron
Names
Preferred IUPAC name
N-(4-Nitrophenyl)-N′-urea
Other names
Pyriminil
Vacor
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.053.279 Edit this at Wikidata
UNII
  • InChI=1S/C13H12N4O3/c18-13(15-9-10-2-1-7-14-8-10)16-11-3-5-12(6-4-11)17(19)20/h1-8H,9H2,(H2,15,16,18) checkY
    Key: CLKZWXHKFXZIMA-UHFFFAOYSA-N checkY
  • InChI=1/C13H12N4O3/c18-13(15-9-10-2-1-7-14-8-10)16-11-3-5-12(6-4-11)17(19)20/h1-8H,9H2,(H2,15,16,18)
    Key: CLKZWXHKFXZIMA-UHFFFAOYAA
  • (=O)c1ccc(cc1)NC(=O)NCc2cccnc2
Properties
C13H12N4O3
Molar mass 272.264 g·mol−1
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
 Toxic
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa).
☒N verify (what is checkY☒N ?)

Pyrinuron (Pyriminil, Vacor) is a chemical compound formerly used as a rodenticide. Commercial distribution was voluntarily suspended in 1979 and it is not approved by the Environmental Protection Agency for use in the United States. If it is ingested by humans in high doses, it may selectively destroy insulin-producing beta cells in the pancreas causing type 1 diabetes. The neurodegeneration associated with Vacor is caused by its conversion to Vacor-mononucleotide (VMN) by NAMPT and VMN's subsequent activation of the NADase SARM1.

References

  1. ^ Vogel, R. P. (1982). "Poisoning with Vacor Rodenticide". Archives of Pathology and Laboratory Medicine. 106 (3): 153. PMID 6895844.
  2. ^ a b "Pyriminil". U.S. National Library of Medicine. Archived from the original on 2013-07-04. Retrieved 2013-11-04.
  3. ^ Loreto, Andrea; Angeletti, Carlo; Gu, Weixi; Osborne, Andrew; Nieuwenhuis, Bart; Gilley, Jonathan; Arthur-Farraj, Peter; Merlini, Elisa; Amici, Adolfo; Luo, Zhenyao; Hartley-Tassell, Lauren (2021-06-23). "Potent activation of SARM1 by NMN analogue VMN underlies vacor neurotoxicity". bioRxiv: 2020.09.18.304261. doi:10.1101/2020.09.18.304261.
Stub icon

This article about an organic compound is a stub. You can help Wikipedia by expanding it.

Wikious
Boobota
Sagapedia