Tetrazolylglycine

Today, Tetrazolylglycine has gained unprecedented relevance in various areas, whether in the world of work, in everyday life or in the academic field. Its influence has become palpable in practically all aspects of our society, generating a significant impact on the way we relate, work and function in the digital environment. This is why it is vitally important to understand and analyze in a deep and critical way the role that Tetrazolylglycine plays in our daily lives, as well as the challenges and opportunities that its presence entails. In this article, we will explore the different aspects related to Tetrazolylglycine and how its presence continues to have a relevant impact on today's society.

Tetrazolylglycine
Chemical structure of tetrazolylglycine
Names
IUPAC name
(RS)-Amino(1H-tetrazol-5-yl)acetic acid
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
UNII
  • InChI=1S/C3H5N5O2/c4-1(3(9)10)2-5-7-8-6-2/h1H,4H2,(H,9,10)(H,5,6,7,8) checkY
    Key: UKBRUIZWQZHXFL-UHFFFAOYSA-N checkY
  • InChI=1/C3H5N5O2/c4-1(3(9)10)2-5-7-8-6-2/h1H,4H2,(H,9,10)(H,5,6,7,8)
    Key: UKBRUIZWQZHXFL-UHFFFAOYAB
  • O=C(O)C(N)c1nnn1
Properties
C3H5N5O2
Molar mass 143.106 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa).
☒N verify (what is checkY☒N ?)

Tetrazolylglycine (Tet-Gly, LY-285,265) is a potent and selective NMDA receptor agonist, stimulating the NMDA receptor with higher potency than either glutamate or NMDA. It is a potent convulsant and excitotoxin and is used in scientific research.

References

  1. ^ Lunn WH, Schoepp DD, Calligaro DO, Vasileff RT, Heinz LJ, Salhoff CR, O'Malley PJ (1992). "DL-tetrazol-5-ylglycine, a highly potent NMDA agonist: its synthesis and NMDA receptor efficacy". Journal of Medicinal Chemistry. 35 (24): 4608–12. doi:10.1021/jm00102a015. PMID 1361579.
  2. ^ Schoepp DD, Smith CL, Lodge D, Millar JD, Leander JD, Sacaan AI, Lunn WH (1991). "D,L-(tetrazol-5-yl) glycine: a novel and highly potent NMDA receptor agonist". European Journal of Pharmacology. 203 (2): 237–43. doi:10.1016/0014-2999(91)90719-7. PMID 1686860.
  3. ^ Schoepp DD, Lunn WH, Salhoff CR, McDonald JW (1994). "The NMDA receptor agonist DL-(tetrazol-5-yl)glycine is a highly potent excitotoxin". European Journal of Pharmacology. 270 (1): 67–72. doi:10.1016/0926-6917(94)90081-7. PMID 8157082.
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