Coriamyrtin

In today's world, Coriamyrtin has become a topic of great relevance and interest to a wide audience. Whether due to its impact on society, its historical relevance, its influence on popular culture or its importance in academia, Coriamyrtin has captured the attention of countless people around the world. In this article, we will explore the different aspects related to Coriamyrtin, analyzing its evolution over time, its many facets and its meaning today. From a multidisciplinary approach, we will seek to understand the role Coriamyrtin plays in our lives and how it has shaped the world we know.

Coriamyrtin
Names
IUPAC name
(1S,2R,3S,5R,6R,7R,9S,12R)-2-Hydroxy-7-methyl-12-prop-1-en-2-ylspirododecane-6,2'-oxirane]-11-one
Other names
Coriamyrtine
Identifiers
3D model (JSmol)
  • InChI=1S/C15H18O5/c1-6(2)8-7-4-13(3)14(5-18-14)10-11(20-10)15(13,17)9(8)12(16)19-7/h7-11,17H,1,4-5H2,2-3H3/t7-,8+,9+,10+,11-,13-,14+,15-/m0/s1
    Key: BWWDLKVKPVKBGJ-TWMZOSGRSA-N
  • CC(=C)C1C2CC3(C4(CO4)C5C(C3(C1C(=O)O2)O)O5)C
Properties
C15H18O5
Molar mass 278.304 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa).

Coriamyrtin is a toxic γ-lactone naturally present in a multitude of plants.

Natural occurrence

Coriamyrtin can be found in Scurrula parasitica, Coriaria microphylla, and certain other plants.

Toxicity

Coriamyrtin is a convulsant. It appears to act via antagonism of GABAA receptors. Poisoning is usually from ingestion of parts of the plants containing it. A case of poisoning was able to be treated with repeated administration of diazepam, an anticonvulsant.

References

  1. ^ "Coriamyrtin".
  2. ^ PubChem. "Scurrula parasitica". pubchem.ncbi.nlm.nih.gov. Retrieved 2024-02-11.
  3. ^ PubChem. "Coriaria microphylla". pubchem.ncbi.nlm.nih.gov. Retrieved 2024-02-11.
  4. ^ "T3DB: Coriamyrtin". www.t3db.ca. Retrieved 2024-02-11.
  5. ^ Pérez, Claudia; Becerra, José; Manríquez-Navarro, Paula; Aguayo, Luis Gerardo; Fuentealba, Jorge; Guzmán, José Leonardo; Joseph-Nathan, Pedro; Jiménez, Verónica; Muñoz, Marcelo Andrés; Silva, Mario (2011). "Inhibitory activities on mammalian central nervous system receptors and computational studies of three sesquiterpene lactones from Coriaria ruscifolia subsp. ruscifolia". Chemical & Pharmaceutical Bulletin. 59 (2): 161–165. doi:10.1248/cpb.59.161. ISSN 1347-5223. PMID 21297293.
  6. ^ de Haro, Luc; Pommier, Philip; Tichadou, Lucia; Hayek-Lanthois, Maryvonne; Arditti, Jocelyne (November 2005). "Poisoning by Coriaria myrtifolia Linnaeus: a new case report and review of the literature". Toxicon: Official Journal of the International Society on Toxinology. 46 (6): 600–603. doi:10.1016/j.toxicon.2005.06.026. ISSN 0041-0101. PMID 16165183.
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