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Oxycodegol

In this article we will explore the different aspects related to Oxycodegol, delving into its importance today and its relevance over time. From its origins to its impact on today's society, we will analyze the many facets of Oxycodegol and its influence in various areas, such as culture, economics, politics and daily life. Through a multidisciplinary approach, we will examine how Oxycodegol has evolved and adapted to the changes of the modern world, and how it continues to be a topic of interest and debate today. Through detailed and critical analysis, this article seeks to shed light on the many aspects of Oxycodegol and its implications for the present and future.

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Oxycodegol
Names
IUPAC name
(4R,4aS,7S,7aR,12bS)-9-methoxy-7-ethoxy]ethoxy]ethoxy]ethoxy]-3-methyl-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuroisoquinolin-4a-ol
Other names
Oxicodegol; Loxicodegol; NKTR-181
Identifiers
3D model (JSmol)
ChemSpider
DrugBank
KEGG
UNII
  • InChI=1S/C31H49NO10/c1-32-9-8-30-27-23-4-5-24(35-3)28(27)42-29(30)25(6-7-31(30,33)26(32)22-23)41-21-20-40-19-18-39-17-16-38-15-14-37-13-12-36-11-10-34-2/h4-5,25-26,29,33H,6-22H2,1-3H3/t25-,26+,29-,30-,31+/m0/s1
    Key: RQHILGKAOIGUHU-XPLSERNMSA-N
  • CN1CC234(CC2(1CC5=C3C(=C(C=C5)OC)O4)O)OCCOCCOCCOCCOCCOCCOC
Properties
C31H49NO10
Molar mass 595.730 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa).

Oxycodegol (also known as loxicodegol and NKTR-181) is an experimental μ-opioid receptor agonist for the treatment of pain.[1][2] It has had success for back pain as an alternative to traditional opioids,[3] which have potential for abuse. It acts more slowly on the central nervous system, reducing risk for abuse and respiratory depression.[1]

References

  1. ^ a b Advokat, Claire D.; Comaty, Joseph E.; Julien, Robert M. (2019). Julien's Primer of Drug Action: a comprehensive guide to the actions, uses, and side effects of psychoactive drugs. New York: Worth Publishers. p. 565. ISBN 978-1-319-20054-1.
  2. ^ "NKTR-181 (Oxycodegol) Oral Tablets for. Chronic Low Back Pain". Food and Drug Administration. Archived from the original on 24 December 2020.
  3. ^ Markman, John; Gudin, Jeffrey; Rauck, Richard; Argoff, Charles; Rowbotham, Matthew; Agaiby, Eva; Gimbel, Joseph; Katz, Nathaniel; Doberstein, Stephen K; Tagliaferri, Mary; Lu, Lin; Saddhanti, Suresh; Hale, Martin (June 2019). "SUMMIT-07: a randomized trial of NKTR-181, a new molecular entity, full mu-opioid receptor agonist for chronic low-back pain". PAIN. 160 (6): 1374–1382. doi:10.1097/j.pain.0000000000001517. PMC 6553961. PMID 30747908.


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