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TRIMU 5

In this article, we will thoroughly explore TRIMU 5 and its relevance in the current context. Since its emergence, TRIMU 5 has caught the attention of many people due to its impact in different spheres. Over the years, TRIMU 5 has evolved and adapted to the changing needs of society, becoming a topic of constant interest. Through this research, we seek to expand the understanding of TRIMU 5 and its influence in various areas, as well as analyze its role in the present and future. By exploring multiple perspectives and reliable sources, it is hoped to provide a comprehensive and enriching view on TRIMU 5 and its importance today.

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TRIMU 5
Names
IUPAC name
L-Tyrosyl-N-{acetyl}-D-alaninamide
Systematic IUPAC name
(2R)-2-Amino-3-(4-hydroxyphenyl)-N-acetamido}-1-oxopropan-2-yl]propanamide
Identifiers
3D model (JSmol)
ChemSpider
  • InChI=1S/C19H30N4O4/c1-12(2)8-9-21-11-17(25)23-18(26)13(3)22-19(27)16(20)10-14-4-6-15(24)7-5-14/h4-7,12-13,16,21,24H,8-11,20H2,1-3H3,(H,22,27)(H,23,25,26)/t13-,16?/m1/s1 checkY
    Key: QOGVSHVPIMZZRN-JBZHPUCOSA-N checkY
  • InChI=1/C19H30N4O4/c1-12(2)8-9-21-11-17(25)23-18(26)13(3)22-19(27)16(20)10-14-4-6-15(24)7-5-14/h4-7,12-13,16,21,24H,8-11,20H2,1-3H3,(H,22,27)(H,23,25,26)/t13-,16?/m1/s1
    Key: QOGVSHVPIMZZRN-JBZHPUCOBN
  • Oc1ccc(C(N)C(=O)N(C)C(=O)NC(=O)CNCCC(C)C)cc1
Properties
C19H30N4O4
Molar mass 378.466
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa).
☒N verify (what is checkY☒N ?)

TRIMU-5 is a selective agonist of the μ2-opioid receptor and antagonist of the μ1-opioid receptor.[1][2] It produces analgesia in animals that differs from that of conventional μ-opioid receptor agonists but that can still be blocked by μ-opioid receptor antagonists.[1] TRIMU-5 can also block the analgesic effects of μ-opioid receptor agonists like morphine.[1] In addition to analgesia, TRIMU-5 inhibits gastrointestinal transit, a known effect of μ2-opioid receptor activation.[1]

References

  1. ^ a b c d Tive LA, Pick CG, Paul D, Roques BP, Gacel GA, Pasternak GW (June 1992). "Analgesic potency of TRIMU-5: a mixed mu 2 opioid receptor agonist/mu 1 opioid receptor antagonist". Eur J Pharmacol. 216 (2): 249–55. doi:10.1016/0014-2999(92)90367-d. PMID 1327812.
  2. ^ Eisenberg RM (1994). "TRIMU-5, a mu 2-opioid receptor agonist, stimulates the hypothalamo-pituitary-adrenal axis". Pharmacol. Biochem. Behav. 47 (4): 943–6. doi:10.1016/0091-3057(94)90300-X. PMID 8029266. S2CID 54354971.


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