HMGB3

In this article, we are going to explore in depth HMGB3 and its impact on different aspects of everyday life. HMGB3 is a topic that has captured the attention of many people in recent times, and it is crucial to understand its implications and applications in various contexts. From its influence on health to its role in society, HMGB3 has proven to be a topic of growing interest that deserves to be analyzed in detail. Throughout this article, we will examine the many facets of HMGB3 and how it has shaped and will continue to shape our world. We will pay special attention to recent advances related to HMGB3 and how these are actively impacting our way of life. Additionally, we will identify the opportunities and challenges arising from HMGB3 and how we can address them.

Protein-coding gene in the species Homo sapiens

HMGB3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EQZ, 2YQI
Identifiers
Aliases	HMGB3, HMG-2a, HMG-4, HMG2A, HMG4, high mobility group box 3
External IDs	OMIM: 300193; MGI: 1098219; HomoloGene: 84734; GeneCards: HMGB3; OMA:HMGB3 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq28 Start 150,980,509 bp[1] End 150,990,771 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A7.3 Start 70,599,524 bp[2] End 70,604,282 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte ganglionic eminence ventricular zone buccal mucosa cell placenta islet of Langerhans olfactory zone of nasal mucosa right lobe of liver mucosa of transverse colon sural nerve Top expressed in ventricular zone ganglionic eminence tail of embryo neural tube mesencephalon genital tubercle lens adrenal gland yolk sac bone marrow More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding double-stranded DNA binding DNA binding, bending protein binding four-way junction DNA binding RNA binding transcription factor binding Cellular component cytoplasm nucleus chromosome Biological process multicellular organism development immune system process DNA recombination innate immune response regulation of transcription, DNA-templated transcription, DNA-templated DNA geometric change negative regulation of B cell differentiation negative regulation of myeloid cell differentiation chromatin remodeling regulation of transcription by RNA polymerase II positive regulation of innate immune response positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3149 15354 Ensembl ENSG00000029993 ENSMUSG00000015217 UniProt O15347 O54879 RefSeq (mRNA) NM_005342 NM_001301228 NM_001301229 NM_001301231 NM_001293623 NM_001293624 NM_001293625 NM_008253 RefSeq (protein) NP_001288157 NP_001288158 NP_001288160 NP_005333 NP_001280552 NP_001280553 NP_001280554 NP_032279 Location (UCSC) Chr X: 150.98 – 150.99 Mb Chr X: 70.6 – 70.6 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

High-mobility group protein B3 is a protein that in humans is encoded by the HMGB3 gene.^[5][6]

References

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000029993 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000015217 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Vaccari T, Beltrame M, Ferrari S, Bianchi ME (April 1998). "Hmg4, a new member of the Hmg1/2 gene family". Genomics. 49 (2): 247–52. doi:10.1006/geno.1998.5214. PMID 9598312.
6. ^ "Entrez Gene: HMGB3 high-mobility group box 3".

Further reading

• Davis DL, Burch JB (April 1992). "Isolation of a chicken HMG2 cDNA clone and evidence for an HMG2-specific 3'-untranslated region". Gene. 113 (2): 251–6. doi:10.1016/0378-1119(92)90403-C. PMID 1572546.
• Shirakawa H, Tsuda K, Yoshida M (May 1990). "Primary structure of non-histone chromosomal protein HMG2 revealed by the nucleotide sequence". Biochemistry. 29 (18): 4419–23. doi:10.1021/bi00470a022. PMID 2350545.
• Wilke K, Wiemann S, Gaul R, Gong W, Poustka A (October 1997). "Isolation of human and mouse HMG2a cDNAs: evidence for an HMG2a-specific 3' untranslated region". Gene. 198 (1–2): 269–74. doi:10.1016/S0378-1119(97)00324-7. PMID 9370291.
• Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

External links

• HMGB3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• PDBe-KB provides an overview of all the structure information available in the PDB for Human High mobility group protein B3 (HMGB3)

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