SALL3

In today's world, SALL3 is a topic that has acquired unprecedented relevance. Its impact extends to all areas of daily life, from politics to popular culture, through technology and society. With the passage of time, SALL3 has become a phenomenon that does not distinguish borders or barriers, since its influence crosses all types of contexts and realities. In this article, we will explore in depth the many facets of SALL3, analyzing its implications and consequences in different areas of daily life.

Protein-coding gene in the species Homo sapiens

SALL3
Identifiers
Aliases	SALL3, ZNF796, spalt-like transcription factor 3, spalt like transcription factor 3
External IDs	OMIM: 605079; MGI: 109295; HomoloGene: 18142; GeneCards: SALL3; OMA:SALL3 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q23 Start 78,979,818 bp[1] End 79,002,677 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 E3 Start 81,009,591 bp[2] End 81,029,986 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence amygdala C1 segment caudate nucleus nucleus accumbens putamen hypothalamus substantia nigra testicle Top expressed in Rostral migratory stream tail of embryo Bowman's capsule epiblast ventricular zone genital tubercle primitive streak olfactory bulb perirhinal cortex embryo More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding metal ion binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process forelimb morphogenesis neurogenesis regulation of transcription, DNA-templated negative regulation of smoothened signaling pathway transcription by RNA polymerase II olfactory bulb interneuron development hindlimb morphogenesis signal transduction transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27164 20689 Ensembl ENSG00000256463 ENSMUSG00000024565 UniProt Q9BXA9 Q62255 RefSeq (mRNA) NM_171999 NM_178280 NM_001369133 RefSeq (protein) NP_741996 NP_840064 NP_001356062 Location (UCSC) Chr 18: 78.98 – 79 Mb Chr 18: 81.01 – 81.03 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sal-like protein 3, also known as zinc finger protein SALL3, is a protein that in humans in encoded by the SALL3 gene.^[5][6]

References

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000256463 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000024565 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "Entrez Gene: sal-like 3 (Drosophila)".
6. ^ Kohlhase J, Hausmann S, Stojmenovic G, Dixkens C, Bink K, Schulz-Schaeffer W, Altmann M, Engel W (December 1999). "SALL3, a new member of the human spalt-like gene family, maps to 18q23". Genomics. 62 (2): 216–22. doi:10.1006/geno.1999.6005. PMID 10610715.

Further reading

• Sweetman D, Münsterberg A (2006). "The vertebrate spalt genes in development and disease" (PDF). Dev. Biol. 293 (2): 285–93. doi:10.1016/j.ydbio.2006.02.009. PMID 16545361. S2CID 45268563.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Shikauchi Y, Saiura A, Kubo T, et al. (2009). "SALL3 interacts with DNMT3A and shows the ability to inhibit CpG island methylation in hepatocellular carcinoma". Mol. Cell. Biol. 29 (7): 1944–58. doi:10.1128/MCB.00840-08. PMC 2655625. PMID 19139273.
• Julií A, Ballina J, Caí±ete JD, et al. (2008). "Genome-wide association study of rheumatoid arthritis in the Spanish population: KLF12 as a risk locus for rheumatoid arthritis susceptibility". Arthritis Rheum. 58 (8): 2275–86. doi:10.1002/art.23623. hdl:10553/50124. PMID 18668548.
• Barbe L, Lundberg E, Oksvold P, et al. (2008). "Toward a confocal subcellular atlas of the human proteome". Mol. Cell. Proteomics. 7 (3): 499–508. doi:10.1074/mcp.M700325-MCP200. PMID 18029348.
• Jugessur A, Shi M, Gjessing HK, et al. (2010). "Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia". PLOS ONE. 5 (7) e11493. Bibcode:2010PLoSO...511493J. doi:10.1371/journal.pone.0011493. PMC 2901336. PMID 20634891.
• de Celis JF, Barrio R (2009). "Regulation and function of Spalt proteins during animal development". Int. J. Dev. Biol. 53 (8–10): 1385–98. doi:10.1387/ijdb.072408jd. hdl:10261/37592. PMID 19247946.

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