In today's world, EA-3148 has become a constant topic of conversation. As society advances, the importance of EA-3148 becomes increasingly evident in different aspects of daily life. From the workplace to the personal, EA-3148 has been shown to have a significant impact on the way people interact with each other and how different situations play out. Over the years, EA-3148 has generated debate and reflection, and has proven to be a relevant topic in the current context. This article will explore different perspectives on EA-3148 and analyze its influence in various areas of modern life.
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Preferred IUPAC name
O-Cyclopentyl S- methylphosphonothioate | |
Identifiers | |
3D model (JSmol)
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ChemSpider | |
PubChem CID
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UNII | |
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Properties | |
C12H26NO2PS | |
Molar mass | 279.378 g/mol |
Density | 1.05 g/cm3 |
Boiling point | 111.11 °C (232.00 °F; 384.26 K) |
Hazards | |
Occupational safety and health (OHS/OSH): | |
Main hazards
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Extremely Toxic |
NFPA 704 (fire diamond) | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa).
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EA-3148 (Substance 100A) is a "V-series" nerve agent related to the better-known compounds VX and VR. It was studied by both the US and Soviet chemical weapons programmes during the Cold War, and is notable as the only V-series organophosphate nerve agent specifically identified in public domain sources as having a higher absolute potency as an acetylcholinesterase inhibitor than VX (around 50% more potent by weight). However, both the US and Soviet investigations of the compound concluded that despite its high potency, the physicochemical properties of the substance made it unsuitable for weaponisation, and further research was not conducted.
The chemical structure of EA-3148 falls within the scope of compounds designated "Toxic chemicals" under Schedule 1 of the Chemical Weapons Convention and so it is illegal throughout the world under international law and may only be used for certain types of scientific and medical research.
A healthy American male soldier was given EA-3148, 1.15 µg/kg i.v.. Erythrocyte AChE values dropped precipitously to 22% of normal within 15 min of dosing and to 0% at 48 h; the value recovered to 88% of normal at 72 days post-exposure. Signs of toxicity were evident within 5-8 min of treatment in two comparably dosed subjects who felt dizzy, weak, tired, sweaty, and had hands and feet that were moist. Within 2 h post-exposure, these subjects reportedly were resting, eating, and feeling fine.
A U.S. Army report summarizing experience with EA-3148 noted anorexia, fatigue, poor sleep, unusual dreams, dizziness, euphoria, blurred vision, increased salivation, restlessness; decrements in a test of numerical facility in four individuals and exaggeration of a schizoid personality in one male soldier.