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BHF-177

Today I want to talk to you about BHF-177. This topic is of utmost importance and relevance today, as it has a significant impact on our lives. Throughout this article, we will explore different aspects related to BHF-177, from its origin to its impact on society. Additionally, we will look at how BHF-177 has evolved over time and what implications it has for the future. Without a doubt, BHF-177 is a topic that deserves our attention and reflection, so I invite everyone to continue reading to discover more about this exciting topic.

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BHF-177
Identifiers
  • N-hept-2-yl]-2-methyl-5--4-pyrimidinamine
CAS Number
IUPHAR/BPS
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC19H20F3N3
Molar mass347.385 g·mol−1
3D model (JSmol)
  • Cc3nc(N2C1CC2C1)c(cn3)c4ccc(cc4)C(F)(F)F
  • InChI=1S/C19H20F3N3/c1-11-23-10-16(13-4-6-15(7-5-13)19(20,21)22)18(24-11)25-17-9-12-2-3-14(17)8-12/h4-7,10,12,14,17H,2-3,8-9H2,1H3,(H,23,24,25)/t12-,14+,17+/m0/s1 checkY
  • Key:ADHZHPOKTRHZGT-DXCKQFNASA-N checkY
  (verify)

BHF-177 is a compound used in scientific research which acts as a positive allosteric modulator at the GABAB receptor.[1] It was shown to reduce self-administration of nicotine in animal studies.[2]

References

  1. ^ Guery S, Floersheim P, Kaupmann K, Froestl W (November 2007). "Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABA B receptors". Bioorganic & Medicinal Chemistry Letters. 17 (22): 6206–11. doi:10.1016/j.bmcl.2007.09.023. PMC 2278029. PMID 17884493.
  2. ^ Paterson NE, Vlachou S, Guery S, Kaupmann K, Froestl W, Markou A (July 2008). "Positive modulation of GABA(B) receptors decreased nicotine self-administration and counteracted nicotine-induced enhancement of brain reward function in rats". The Journal of Pharmacology and Experimental Therapeutics. 326 (1): 306–14. doi:10.1124/jpet.108.139204. PMC 2574924. PMID 18445779.
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